The crystallographic structures of both the vanadium chloroperoxidase and bromoperoxidase enzymes have been determined with either vanadium or phosphate bound at their active site. The amino acids that are involved in phosphate binding in the acid phosphatase enzymes and those that are coordinated to vanadium in the haloperoxidases appear to be conserved between the two classes of enzyme. The detailed active site architecture for enzymes that recognize and use either vanadium or phosphate will be discussed in relation to their proposed enzymatic mechanism.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jmr.590 | DOI Listing |
Publication Analysis
Top Keywords
acid phosphatase
8
phosphatase enzymes
8
vanadium phosphate
8
active site
8
vanadium
5
structural functional
4
functional comparisons
4
comparisons vanadium
4
vanadium haloperoxidase
4
haloperoxidase acid
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!