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Discovery of novel flavonoid derivatives containing benzothiazole as potential antifungal agents.
Pest Manag Sci
January 2025
State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, China.
Background: Fungal diseases of plants have a serious impact on the quality and yield of crops, and some traditional pesticides can no longer cope with this problem. Therefore, it is of great significance to develop new pesticides with high efficiency and low toxicity.
Results: A series of flavonoid derivatives containing benzothiazole were designed and synthesized.
SUMOylation Inhibitors Exert a Protective Effect on Oxidative Damage in Retinal Pigment Epithelial Cells Through the Keap1/Nrf2/ARE Signaling Pathway.
Curr Mol Med
January 2025
Department of Ophthalmology, Hebei Medical University, Shijiazhuag 050017, Hebei, China.
Article Synopsis
- The study aimed to assess how the SUMOylation inhibitor TAK981 affects oxidative damage caused by hydrogen peroxide (H2O2) in human retinal pigment epithelial cells (ARPE-19) and its underlying mechanisms.
- An oxidative damage model was created, and various concentrations of TAK981 were tested to see their impact on cell viability, levels of oxidative stress markers, and inflammatory cytokines, while comparing them to control and model groups.
- Results showed that H2O2 reduced cell viability significantly, while TAK981 treatment improved cell survival and reduced oxidative damage and inflammation markers, indicating its potential protective effects against oxidative stress in ARPE-19 cells.
Lutein Exerts Antioxidant and Neuroprotective Role on Schizophrenia-Like Behaviours in Mice.
Int J Dev Neurosci
February 2025
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Schizophrenia is an esteemed neuropsychiatric condition delineated by the manifestation which role of the N-methyl-D-aspartate receptor (NMDAR) is important. Lutein administration exhibits protective effects via NMDA receptors. Thus, the main goal of this research was to investigate how lutein can possibly act as an antioxidant and provide protection for the brain against schizophrenia-like behaviours in mice.
View Article and Find Full Text PDFFunctional crosstalk of sucrose and G protein signaling in maize thermotolerance by modulating osmoregulation system.
Protoplasma
December 2024
School of Life Sciences, Yunnan Normal University, Kunming, 650092, People's Republic of China.
Sucrose (SUC) is a signaling molecule with multiple physiological functions. G protein is a kind of receptor that converts extracellular first messenger into intracellular second messenger. However, it is little known that SUC interplays with G protein signaling in maize thermotolerance.
View Article and Find Full Text PDFMefunidone Inhibits Inflammation, Oxidative Stress, and Epithelial-Mesenchymal Transition in Lens Epithelial Cells.
Invest Ophthalmol Vis Sci
December 2024
Eye Center of Xiangya Hospital, Central South University, Changsha, China.
Purpose: Inflammation, oxidative stress, and epithelial-mesenchymal transition (EMT) play crucial roles in forming posterior capsular opacification (PCO), particularly in fibrotic PCO. Here we investigated the protective effects of mefunidone (MFD), a novel compound with potent antifibrotic properties, which could be useful in preventing PCO.
Methods: We utilized an extracapsular lens extraction (ECLE) surgery in mice to simulate the development of PCO in vivo.
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