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Algorithm for the Identification of Hemoglobin Wayne Interference on Hb A1c Measurement Using Intact Hemoglobin Protein Mass Spectrometry Analysis.
J Appl Lab Med
November 2024
Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH, United States.
The Hemoglobin Wayne Variant and Association With Falsely Elevated HbA.
JCEM Case Rep
May 2023
UT Southwestern Medical Center, Department of Internal Medicine, Dallas, TX 75390, USA.
The objective of this work is to explain the effect of the clinically silent hemoglobinopathy hemoglobin Wayne (Hb Wayne) variant on glycated hemoglobin A (HbA) assay. This variant can result in falsely high HbA values among euglycemic individuals without diabetes mellitus (DM). We discuss 3 patients who were diagnosed with type 2 DM based on spuriously high HbA values due to the presence of Hb Wayne.
View Article and Find Full Text PDFHemoglobin Wayne: A Rare Variant That Can Cause Falsely Elevated Hemoglobin A1c.
Cureus
July 2022
Internal Medicine, Hackensack Meridian Health Ocean Medical Center, Brick, USA.
Hemoglobin A1c (HbA1c) can be unreliable (falsely elevated or lowered) in certain conditions, including hemoglobinopathies, anemia, lead poisoning, chronic alcoholism, and opioid use. Hemoglobin Wayne is a rare variant of hemoglobin (Hgb) that can also result in a false elevation of HbA1c. Hence, clinicians should be aware of these underlying causes before diagnosing and treating diabetes mellitus to avoid unexpected consequences.
View Article and Find Full Text PDFHemoglobin Wayne causing a falsely elevated hemoglobin A1c.
Proc (Bayl Univ Med Cent)
October 2021
Division of Endocrinology, Department of Medicine, Baylor Scott & White Medical Center - Temple, Temple, Texas.
Hemoglobin A1c (HbA1c) is an important tool for diagnosis and management of patients with diabetes mellitus (DM). However, hemoglobin variants can interfere with laboratory assays and lead to inaccurate results. This study describes a patient who was found to have falsely elevated HbA1c values secondary to hemoglobin Wayne, a rare hemoglobin variant.
View Article and Find Full Text PDFA Patient With Discordant Hemoglobin A1c Results.
Clin Chem
July 2020
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.
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