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| http://dx.doi.org/10.1136/bjo.86.12.1448 | DOI Listing |
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MARCH5 ameliorates aortic valve calcification via RACGAP1-DRP1 pathway associated mitochondrial quality control.
Biochim Biophys Acta Mol Cell Res
January 2025
Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu 610041, PR China; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Cardiac Structure and Function Research Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, PR China. Electronic address:
Background: Mitochondrial E3 ubiquitin ligase (MARCH5) as an important regulator in maintaining mitochondrial function. Our aims were to investigate the role and mechanism of MARCH5 in aortic valve calcification.
Methods: Human aortic valves, both calcified and non-calcified, were analyzed for MARCH5 expression using western blot.
Microplastic and microfiber contamination in the Tiber River, Italy: Insights into their presence and chemical differentiation.
Mar Pollut Bull
January 2025
Institute of Aquatic Ecology, HUN-REN Centre for Ecological Research, Karolina út 29-31, H-1113 Budapest, Hungary; National Laboratory for Water Sciences and Water Security, Institute of Aquatic Ecology, HUN-REN Centre for Ecological Research, Karolina út 29-31, H-1113 Budapest, Hungary; Institute of Chemistry, Eötvös Loránd University, Pázmány Péter sétány 1/A, H1113 Budapest, Hungary. Electronic address:
Microplastics (MPs) are an emerging environmental concern, but studies on these contaminants, particularly in river ecosystems, remain scarce. Research has indicated that MPs in the environment are predominantly microfibers (MFs); however, a few studies suggest that the MFs encountered are chiefly of natural origin. In this study, we aimed to improve the understanding of MP/MFs (both plastic and natural), among microparticle (solid particles >10 μm to <5000 μm; mainly of plastic as well as natural origin) loads in the Tiber River, Italy, by analyzing the physicochemical properties of surface water and assessing the abundance and characteristics of MPs-MFs at three sites: Ponte Grillo, Aniene, and Magliana, along a 60 km stretch.
View Article and Find Full Text PDFABC-type salt tolerance transporter genes are abundant and mutually shared among the microorganisms of the hypersaline Sambhar Lake.
Extremophiles
January 2025
Microbiology Laboratory, Department of Botany (DST-FIST and UGC-DRS Funded), Institute of Science, Visva-Bharati (A Central University), Santiniketan, West Bengal, 731235, India.
To fish-out novel salt-tolerance genes, metagenomic DNA of moderately saline sediments of India's largest hypersaline Sambhar Lake was cloned in fosmid. Two functionally-picked clones helped the Escherichia coli host to tolerate 0.6 M NaCl.
View Article and Find Full Text PDFMicroplastics in rivers of Gujarat (India) until the Arabian Sea: assessment of the sources, distribution and associated environmental risk.
Integr Environ Assess Manag
January 2025
Mu Gamma Consultants Pvt. Ltd, Gurgaon, India, 122018.
Microplastics (MPs) have become a notable concern and are released into the environment through the disposal or fragmentation of large plastics. Rivers have been the major pathways for MPs present in the oceans, which significantly affects the marine environment. In the current study, water samples were collected from the upper stream and downstream of Damanganga and Tapi rivers across different sites in the state of Gujarat, India for exploration of MPs contamination.
View Article and Find Full Text PDFEffect of Bacterial Nanocellulose with Chemisorbed Antiseptics on Alveolar Bone Repair in Rats Undergoing Bisphosphonate Therapy.
Pharmaceutics
December 2024
Post-Graduate Program in Dentistry, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre 90619-900, RS, Brazil.
: This work investigated the effect of bacterial nanocellulose (BNC) alone or with chemisorbed chlorhexidine or povidone-iodine on post-tooth extraction repair in rats undergoing bisphosphonate therapy. : Forty Wistar rats were treated with zoledronic acid, subjected to tooth extractions and allocated into groups according to the material inserted in the post-extraction socket: (1) BNC ( = 10); (2) BNC/Iodine ( = 10); (3) BNC/Chlorhex ( = 10); (4) Control ( = 10). Maxillae were dissected and macro- and microscopically analyzed.
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