The crystal structure of a gp120/CD4/Fab17b complex was analysed leading to the design of several peptide libraries in the hope of obtaining novel gp120/cell membrane receptor interaction inhibitors, especially inhibitors of gp120/CD4 and gp120/chemokine receptor interactions. Syntheses of tri- and tetra- and pentapeptides were performed via a solid phase synthesis methodology using a Rink Amide MBHA resin and a Fmoc strategy giving C-terminal amide form peptides. Compounds were assayed against C8166 cells infected by HIV-1 IIIB and screened using a gp120 binding assay and the FIGS reporter gene assay.

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0223-5234(02)01412-5DOI Listing

Publication Analysis

Top Keywords

peptide libraries
8
gp120/cell membrane
8
crystal structure
8
design synthesis
4
synthesis evaluation
4
evaluation peptide
4
libraries potential
4
potential anti-hiv
4
anti-hiv compounds
4
compounds inhibition
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!