The pyridoacridine family tree: a useful scheme for designing synthesis and predicting undiscovered natural products.

J Nat Prod

Center for New Directions in Organic Synthesis, Department of Chemistry, University of California Berkeley, Berkeley, California 94720, USA.

Published: November 2002

The pyridoacridine natural products represent a large and growing class and serve here to illustrate the wealth of information that can be extracted by comparing natural products on the basis of structure and occurrence.

Download full-text PDF

Source
http://dx.doi.org/10.1021/np020016yDOI Listing

Publication Analysis

Top Keywords

natural products
12
pyridoacridine family
4
family tree
4
tree scheme
4
scheme designing
4
designing synthesis
4
synthesis predicting
4
predicting undiscovered
4
undiscovered natural
4
products pyridoacridine
4

Similar Publications

Multiple porcine reproductive and respiratory syndrome virus (PRRSV) subtypes coinfect numerous pig farms in China, and commercial PRRSV vaccines offer limited cross-protection against heterologous strains. Our previous research confirmed that a PRRSV lineage 1 branch attenuated live vaccine (SD-R) provides cross-protection against HP-PRRSV, NADC30-like PRRSV and NADC34-like PRRSV. HP-PRRSV has undergone significant genetic variation following nearly two decades of evolution and has transformed into a subtype referred to as HP-like PRRSV, which also exhibits high pathogenicity.

View Article and Find Full Text PDF

In-stent restenosis (ISR) following interventional therapy is a fatal clinical complication. Current evidence indicates that neointimal hyperplasia driven by uncontrolled proliferation of vascular smooth muscle cells (VSMC) is a major cause of restenosis. This implies that inhibiting VSMC proliferation may be an attractive approach for preventing in-stent restenosis.

View Article and Find Full Text PDF

Bibliometric analysis of glycolysis and prostate cancer research from 2004 to 2024.

Discov Oncol

January 2025

School of Rehabilitation Medicine and Health Care, Hunan University of Medicine, No. 492 Jinxi South Road, Huaihua, 418000, China.

Background: Prostate cancer (PCa) ranks as the second most common disease among men and the fourth most prevalent cancer worldwide. Enhanced glycolysis and excessive lactate secretion are recognized as critical factors driving the progression of various cancers. This study systematically investigated the research trends associated with glycolysis in PCa through bibliometric analysis.

View Article and Find Full Text PDF

Synthetic biology meets Aspergillus: engineering strategies for next-generation organic acid production.

World J Microbiol Biotechnol

January 2025

School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, No. 1 Wenyuan Road, Nanjing, 210023, People's Republic of China.

Organic acids constitute a vital category of chemical raw materials. They have extensive applications in industries such as polymers, food, and pharmaceuticals. Currently, industrial production predominantly relies on microbial fermentation.

View Article and Find Full Text PDF

Purinergic signaling plays a major role in aging and neurodegenerative diseases, which are associated with memory decline. Blackcurrant (BC), an anthocyanin-rich berry, is renowned for its antioxidant and neuroprotective activities. However, evidence on the effects of BC on purinergic signaling is lacking.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!