Two new resveratrol tetramers, hopeaphenol A (1) and isohopeaphenol A (2), along with the known vaticaphenol A (3), were isolated from the stem bark of Vatica oblongifolia ssp. oblongifolia through bioassay-guided fractionation. The structures and their relative stereochemistry were determined by spectroscopic techniques. Compounds 1 and 3 demonstrated moderate activity against methicillin-resistant Staphylococcus aureus and Mycobacterium smegmatis.
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J Agric Food Chem
January 2025
Université de Reims Champagne Ardenne, INRAE, RIBP USC 1488, 51100 Reims, France.
Stilbenes are specialized metabolites that are particularly abundant in species. Although the biosynthetic pathways of stilbenes have been well-characterized, the role of specific peroxidases in stilbene oligomerization remains to be investigated. In this study, we used grapevine cell cultures to characterize the functional role of peroxidase 4 (VvPRX4) in the production of resveratrol oligomers after elicitation with methyl jasmonate (MeJA).
View Article and Find Full Text PDFJ Med Chem
November 2024
Molecular Nutrition Group, Department of Nutrition, Dietetics and Food, Monash University, Victorian Heart Institute, Victoria Heart Hospital, 631 Blackburn Road, Clayton, VIC 3168, Australia.
A key strategy to mitigate postprandial hyperglycemia involves inhibiting α-amylases, which commence the starch digestion process in the gut. This study examined the inhibitory effects of resveratrol and stilbenoid tetramers, vaticanol B, (-)-hopeaphenol, and vatalbinoside A on human salivary and pancreatic α-amylases experimentally and through molecular docking studies. Vaticanol B demonstrated the most potent inhibition with IC values of 5.
View Article and Find Full Text PDFAdv Pharmacol Pharm Sci
October 2024
Centro de Investigación en Alimentación y Desarrollo, A.C. Carretera Gustavo Enrique Astiazarán Rosas 46, La Victoria, Hermosillo CP. 83304, Sonora, Mexico.
Molecules
August 2024
Department of Experimental and Functional Morphology, Institute of Botany, Czech Academy of Sciences, Dukelská 135, 379 01 Třeboň, Czech Republic.
Stilbenes in the roots of and were studied. Root samples were extracted with 100% methanol and analyzed by HPLC and LC-MS. In this way, -resveratrol dimers (/ 455 Da [M + H]), trimers (/ 681 Da [M + H]) and tetramers (/ 907 Da [M + H]) were identified in the extracts.
View Article and Find Full Text PDFHeliyon
January 2024
Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya, 468-8503 Japan.
In tropical Southeast Asia, is the most economically important tree and the largest genus in the Dipterocarpaceae family. It comprises about 150-200 species, of which majority are distributed in Malaysia, with others found in Sumatra and Borneo (Kalimantan) in Indonesia. Research on the chemical constituents of plants has been ongoing for many years.
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