Antimicrobial resveratrol tetramers from the stem bark of Vatica oblongifoliassp. oblongifolia.

J Nat Prod

Graduate Program in Pharmacognosy, Department of Chemistry and Biochemistry, and Department of Biological Sciences, University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, Pennsylvania 19104-4495, USA.

Published: November 2002

Two new resveratrol tetramers, hopeaphenol A (1) and isohopeaphenol A (2), along with the known vaticaphenol A (3), were isolated from the stem bark of Vatica oblongifolia ssp. oblongifolia through bioassay-guided fractionation. The structures and their relative stereochemistry were determined by spectroscopic techniques. Compounds 1 and 3 demonstrated moderate activity against methicillin-resistant Staphylococcus aureus and Mycobacterium smegmatis.

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http://dx.doi.org/10.1021/np020198wDOI Listing

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