AI Article Synopsis
- The study explores the link between gene polymorphisms in the renin-angiotensin system and predispositions to essential hypertension and cardiovascular diseases.
- Previous research has shown mixed results regarding the impact of the aldosterone synthase (CYP11B2) gene polymorphism on hypertension risk.
- The current case-control study found a significant association between the -344C/C polymorphism of the CYP11B2 gene and an increased likelihood of developing essential hypertension, with a higher frequency of the C allele observed in hypertensive patients compared to normotensive individuals.
Article Abstract
Predispositions to essential hypertension and cardiovascular diseases are possibly associated with gene polymorphisms of the renin-angiotensin system. Gene polymorphisms of angiotensinogen and angiotensin-converting enzyme genes have been suggested to be risk factors for hypertension and myocardial infarction. Concerning the polymorphism of aldosterone synthase (CYP11B2) gene, earlier studies have shown inconsistent results in terms of its relation to hypertension. In the present case-control study, we investigated the association of -344T/C polymorphism in the promoter region of human CYP11B2 gene with genetic predisposition to hypertension. The genotype of -344T/C polymorphism was determined in essential hypertension subjects (n=250) and normotensive subjects (n=221). The distributions of three genotypes (TT, TC, and CC) were significantly different between the hypertensive and the normotensive groups (chi(2)=9.61, P=0.008). Namely, the frequency of C allele was higher in the hypertensive patients than in the normotensive subjects (34.2 vs 26.5%, P=0.010). Our data suggest that the -344C allele of CYP11B2 gene polymorphism is associated with the genetic predisposition to develop essential hypertension.
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| http://dx.doi.org/10.1038/sj.jhh.1001484 | DOI Listing |
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Article Synopsis
- * It finds that certain genes are unmethylated in the zona fasciculata (ZF) but heavily methylated in the zona glomerulosa (ZG) and reticularis (ZR), affecting the expression of CYP11B enzymes.
- * The results suggest that aldosterone synthesis might occur in the adrenal medulla, and further research is needed to understand its implications.
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