Synthesis and biological evaluation of novel 2-(1H-imidazol-4-yl)cyclopropane carboxylic acids: key intermediates for H3 histamine receptor ligands.

Bioorg Med Chem Lett

Departamento de Ciencias Qui;micas, Sección de Qui;mica Orgánica y Farmacéutica, Universidad San Pablo CEU, Urb Montepríncipe, Boadilla del Monte 28668, Madrid, Spain.

Published: December 2002

A new synthetic methodology to provide cis-2-(1H-imidazol-4-yl)-cyclopropane carboxylic acids is described. These cyclopropanes are useful for the preparation of novel H(3) receptor agents.

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Source
http://dx.doi.org/10.1016/s0960-894x(02)00793-xDOI Listing

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