Synthesis and characterization of adenosine adducts of arylamines.

Nucleosides Nucleotides Nucleic Acids

Department of Studies in Chemistry, University of Mysore, India.

Published: April 2003

The synthesis of adducts of arylamines with adenosine are reported.

Download full-text PDF

Source
http://dx.doi.org/10.1081/NCN-120014818DOI Listing

Publication Analysis

Top Keywords

adducts arylamines
8
synthesis characterization
4
characterization adenosine
4
adenosine adducts
4
arylamines synthesis
4
synthesis adducts
4
arylamines adenosine
4
adenosine reported
4
synthesis
2
adenosine
2

Similar Publications

Article Synopsis
  • Dietary isothiocyanates (ITCs) from cruciferous vegetables could positively impact the prognosis of non-muscle invasive bladder cancer (NMIBC) by possibly reducing progression risk, especially in individuals with certain genetic variations.
  • The study analyzed data from 1,472 NMIBC patients, assessing their dietary intake of cruciferous vegetables and measuring ITC levels in their blood, using advanced statistical methods to determine the relationship between these factors and cancer outcomes based on specific gene variants.
  • Results showed that while some genetic variations did affect the relationship between dietary ITCs and progression risk, a high intake of cruciferous vegetables was associated with a significant reduction in progression risk for most participants, suggesting dietary recommendations could enhance NMIBC survivorship.
View Article and Find Full Text PDF

Sequence context influences structural characteristics and repair of DNA adducts, but there is limited information on how epigenetic modulation affects conformational heterogeneity and bypass of DNA lesions. Lesions derived from the environmental pollutant 2-nitrofluorene have been extensively studied as chemical carcinogenesis models; they adopt a sequence-dependent mix of two significant conformers: major groove binding (B) and base-displaced stacked (S). We report a conformation-dependent bypass of the N-(2'-deoxyguanosin-8-yl)-7-fluoro-2-aminofluorene (dG-FAF) lesion in epigenetic sequence contexts (d[5'-CTTCTC#G*NCCTCATTC-3'], where C# is C or 5-methylcytosine (5mC), G* is G or G-FAF, and N is A, T, C or G).

View Article and Find Full Text PDF

Selective Oxidative Methyl C-H Functionalization of Butylated Hydroxytoluene toward Arylimines/-Heterocycles.

J Org Chem

October 2023

Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.

A metal-free and selective oxidative methyl C-H functionalization of BHT with aniline compounds has been developed. This innovative method enables the facile and efficient synthesis of a diverse array of BHT-functionalized -containing skeletons, including arylamines, benzoxazoles, benzothiazoles, benzimidazoles, quinazolines, and quinazolinones, all of which are challenging to access. The control experiment involving TEMPO suggests that the radical adduct of TEMPO with the benzyl radical of BHT may serve as an intermediate.

View Article and Find Full Text PDF

N-OH-AABP Modifications in Human DNA May Lead to Auto-Antibodies in Bladder Cancer Subjects.

Diagnostics (Basel)

January 2022

Department of Medical Laboratory Sciences, College of Applied medical Sciences, University of Hail, Hail 2440, Saudi Arabia.

4-Aminobiphenyl (4-ABP) and other related arylamines have emerged to be responsible for human urinary bladder tumors and cancers. Hemoglobin-ABP adducts have been recognized in the blood of smokers, and it builds up in the circulatory system over the period of years that might lead to a bladder tumor. N-hydroxy-Acetyl 4-Aminobiphenyl (N-OH-AABP) is one of the reactive forms of 4-ABP which has a potential to initiate tumor growth and causes cancer rapidly.

View Article and Find Full Text PDF

Identification and characterization of potent, selective, and efficacious inhibitors of human arylamine N-acetyltransferase 1.

Arch Toxicol

February 2022

Department of Pharmacology and Toxicology, University of Louisville Health Science Center, University of Louisville, Kosair Charities Clinical and Translational Research Building Room 303, 505 South Hancock Street, Louisville, KY, 40202-1617, USA.

Arylamine N-acetyltransferase 1 (NAT1) plays a pivotal role in the metabolism of carcinogens and is a drug target for cancer prevention and/or treatment. A protein-ligand virtual screening of 2 million chemicals was ranked for predicted binding affinity towards the inhibition of human NAT1. Sixty of the five hundred top-ranked compounds were tested experimentally for inhibition of recombinant human NAT1 and N-acetyltransferase 2 (NAT2).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!