Measurement of the blood lipid peroxidation products (lipid hydroperoxides, dienic ketones, and malonic dialdehyde) was carried out in 26 patients with stable angina of effort and in 31 patient with postinfarction cardiosclerosis with due regard for the ejection fraction (intact, reduced) before treatments administration and after institution of antianginal therapy (nitrates, beta-adrenoblockers, nifedipine). The antianginal therapy has been shown to have but insignificant effect on both blood plasma contents of dienic ketones and plasma/erythrocyte content of malonic dialdehyde, which fact is regarded as an indication for use of antioxidant agents.
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Yonsei Med J
December 2024
Department of Hematology, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea.
A 55-year-old male with hemophilia A came to the outpatient clinic with chest pain for several days after overdose injection of coagulation factor. He was a heavy smoker and a chronic alcoholic. An electrocardiogram (ECG) showed no specific change.
View Article and Find Full Text PDFJ Assoc Physicians India
November 2024
Director, Department of Medical Affairs, Dr Reddy's Laboratories Ltd., Ameerpet, Hyderabad, Telangana, India.
Kardiologiia
October 2024
Hertsen Moscow Oncology Research Institute, Branch of the National Medical Research Radiological Center.
The article presents a clinical case of perioperative non-ST-segment elevation myocardial infarction in a patient with primary metasynchronous cancer of the rectum, stomach and bladder, which developed during simultaneous surgical intervention in the volume of proximal gastrectomy and abdominoperineal extirpation of the rectum. Fluctuations in blood pressure and imbalance in the hemostasis system at the stages of anesthesia and surgery in a patient with severe systemic atherosclerosis caused the development of myocardial ischemia in the area of significant coronary stenosis. Emergency coronary angiography detected subtotal stenosis of the anterior descending artery; stenting of the affected area of the coronary artery was performed.
View Article and Find Full Text PDFLung Cancer
November 2024
Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China; Department of Medicine, Shenzhen Hong Kong University Hospital, China; Genetics Research Program for Personalized Medicine in Cardiac Oncology, The University of Hong Kong, Hong Kong SAR, China.
Background: Metabolic re-wiring with preferential fatty acid oxidation has been observed in lung cancer cells. Whether the use of trimetazidine, an anti-anginal agent that inhibits fatty acid oxidation, alters clinical outcomes in ischemic heart disease (IHD) patients with lung cancers is unknown.
Methods: We carried out this territory-wide, retrospective cohort study of 279,894 IHD patients prescribed with trimetazidine or long-acting oral nitrates in Hong Kong (population coverage of 7.
Eur J Pharmacol
December 2024
Department of Pharmacology, Therapeutics & Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Idi-Araba, P.M.B. 12003, Lagos, Nigeria. Electronic address:
Trimetazidine (TMZ) is a beneficial and well-tolerable anti-anginal drug which has protective action towards ischemia and reperfusion injury. TMZ performs its anti-ischemic effect by modifying cardiac metabolism without shifting the hemodynamic functions, so it represents an outstanding complementary perspective to the general angina treatment. TMZ possesses a positive impact on the inflammatory profile, and also endothelial function furthermore displays various benefits through minimising the number, as well as the intensity of angina strikes and ameliorating the clinical indication and symptoms of myocardium ischemia.
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