Ocular manifestations of systemic lupus erythematosus.

Curr Opin Ophthalmol

Retina and Vitreous Service, Clinica Oftalmologica, Centro Caracas PH-1, Av. Panteon, San Bernardino, Caracas 1010, Venezuela.

Published: December 2002

AI Article Synopsis

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can impact various body systems, especially the eyes.
  • The most common eye issue related to SLE is keratoconjunctivitis sicca, but serious vision problems often arise from retinal and neuro-ophthalmic complications.
  • Ophthalmologists should monitor patients with eye-related lupus symptoms closely for signs of systemic disease, as these eye issues can indicate more serious health problems elsewhere.

Article Abstract

Systemic lupus erythematosus (SLE) is a chronic, immunologic disorder that may affect multiple organ systems. Keratoconjunctivitis sicca is the most common ocular manifestation, but visual morbidity is usually due to retinal and neuro-ophthalmic manifestations of the disease. Ocular manifestations of lupus are a reflection of systemic disease. The presence of ocular manifestations should alert the clinician to the likely presence of disease activity elsewhere. Therefore, all patients with ocular lupus should be carefully evaluated for systemic involvement to detect potentially treatable and preventable complications of the disease. In addition, the ophthalmologist should include SLE in the differential diagnosis of many retinal vascular and neuro-ophthalmic disorders. The ophthalmologist may play an important role in the care of patients with SLE, since ocular inflammatory lesions may precede potentially serious extraocular disease.

Download full-text PDF

Source
http://dx.doi.org/10.1097/00055735-200212000-00011DOI Listing

Publication Analysis

Top Keywords

ocular manifestations
12
systemic lupus
8
lupus erythematosus
8
ocular
6
disease
5
systemic
4
manifestations systemic
4
lupus
4
erythematosus systemic
4
erythematosus sle
4

Similar Publications

Anderson-Fabry Disease: Focus on Ophthalmological Implications.

Life (Basel)

November 2024

Rare, Degenerative and Inflammatory Ocular Diseases Unit, Department of Sense Organs, La Sapienza University, Viale del Policlinico 155, 00161 Rome, Italy.

Fabry disease (FD) is a rare X-linked lysosomal storage disorder with a broad spectrum of clinical manifestations, including severe complications, such as end-stage renal disease, hypertrophic cardiomyopathy, and cerebrovascular disease. Enzyme replacement therapy (ERT), when initiated early, has been shown to reduce the incidence of severe events and slow disease progression. In the classic form, characterized by the absence of α-galactosidase A (α-Gal A) enzyme activity, diagnosis is straightforward.

View Article and Find Full Text PDF

Advances in Corneal Diagnostics Using Machine Learning.

Bioengineering (Basel)

November 2024

Department of Electrical & Electronic Engineering, College of Engineering, Universiti Tenaga Nasional, Kajang 43000, Malaysia.

This paper provides comprehensive insights into the cornea and its diseases, with a particular focus on keratoconus. This paper explores the cornea's function in maintaining ocular health, detailing its anatomy, pathological conditions, and the latest developments in diagnostic techniques. Keratoconus is discussed extensively, covering its subtypes, etiology, clinical manifestations, and the application of the Q-value for quantification.

View Article and Find Full Text PDF

Thyroid eye disease (TED) is a common extrathyroidal manifestation of hyperthyroidism, typically associated with Graves' disease (GD). This condition can cause severe functional limitations as well as significant aesthetic concerns. Treatment for TED patients aims to restore functionality and address aesthetic concerns.

View Article and Find Full Text PDF

Ocular Manifestations of IBD: Pathophysiology, Epidemiology, and Iatrogenic Associations of Emerging Treatment Strategies.

Biomedicines

December 2024

Department of Gastroenterology, The Royal Wolverhampton NHS Trust, Wolverhampton WV10 0QP, UK.

Inflammatory bowel disease (IBD) is a complex, multisystemic disease and is associated with ocular pathology in 4-12% of patients. In general, ocular disease affects Crohn's patients more frequently than those with ulcerative colitis. Episcleritis and uveitis are the most common presentations, with episcleritis often correlating with IBD flares, whereas uveitis presents independently of IBD activity and, in some cases, may even alert clinicians to a new diagnosis of IBD.

View Article and Find Full Text PDF

Rheumatic Manifestations of Sarcoidosis.

Diagnostics (Basel)

December 2024

North Bristol NHS Foundation Trust, Bristol BS10 5NB, UK.

Sarcoidosis is a multisystem granulomatous inflammatory disorder, of unknown aetiology, which causes a wide spectrum of clinical phenotypes. It can present at any age, most commonly between 20 and 60 years, with a roughly equal sex distribution. Diagnosis is often delayed due to multiple diagnostic mimics, particularly joint disease.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!