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Enteropathic SAPHO Syndrome in Ulcerative Colitis Responsive to Bisphosphonates.
Case Rep Rheumatol
October 2024
Division of Rheumatology, Mayo Clinic, Jacksonville 32224, Florida, USA.
SAPHO syndrome, a rare inflammatory disorder of bone, joints, and skin, is named based on the presence of synovitis, acne, pustulosis, hyperostosis, and osteitis. The hallmark of SAPHO syndrome includes osteoarticular and dermatologic manifestations, however, rarer associations with inflammatory bowel disease (particularly Crohn's disease) have been documented. The literature on the relationship between SAPHO syndrome and inflammatory bowel disease (IBD), especially ulcerative colitis (UC), remains limited.
View Article and Find Full Text PDFLong-term effectiveness of the combination of iguratimod and alendronate in SAPHO syndrome: a prospective cohort study.
Rheumatology (Oxford)
November 2024
Department of Orthopedics Medicine, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China.
Objective: To evaluate the long-term effectiveness of the combination of Iguratimod (IGU) and Alendronate for patients with Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) syndrome.
Methods: A prospective cohort study was conducted on patients diagnosed with SAPHO syndrome at Peking University Third Hospital and Beijing Jishuitan Hospital from 2017 to 2024. The initial treatment regimen comprised a combination of IGU and Alendronate.
Challenges in Diagnosing SAPHO Syndrome: A Multidisciplinary Perspective.
Cureus
October 2024
Internal Medicine, Islamic International Medical College, Rawalpindi, PAK.
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis syndrome) is a systemic inflammatory disease characterized by a combination of both osteoarticular and dermatological manifestations. We encountered an interesting case of a 54-year-old female patient who presented with symptoms of recurrent chest infections. Extensive investigations, including laboratory tests and imaging, were conducted with an initial suspicion of malignancy, but the patient was ultimately diagnosed with SAPHO.
View Article and Find Full Text PDFThe challenging diagnosis of synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome: A rare case report.
SAGE Open Med Case Rep
May 2024
Radiology Department, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
Considered rare, the synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is a distinct clinical entity, associating skin manifestations and osteoarticular symptoms. Anterior chest wall pain centered at sternoclavicular and sternocostal joints is an important and characteristic clinical finding that can lead to its diagnosis. Radiologists and clinicians must be aware of synovitis-acne-pustulosis-hyperostosis-osteitis syndrome as it can mimic some of the more common disease entities such as Paget's disease.
View Article and Find Full Text PDFSuccessful Treatment of Refractory Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome with Baricitinib, a Janus Kinase Inhibitor.
Clin Cosmet Investig Dermatol
March 2024
Department of Dermatology, Dushu Lake Hospital Affiliated to Soochow University (Medical Center of Soochow University), Suzhou, People's Republic of China.
Article Synopsis
- SAPHO syndrome is a rare inflammatory disease that is hard to diagnose and treat due to its various symptoms, lack of specific tests, and limited treatment options focused mainly on symptom relief.
- A case study details a 32-year-old Chinese woman with severe joint pain and skin lesions, who did not respond well to standard treatments like NSAIDs and biologics.
- After starting baricitinib, a JAK inhibitor, she saw significant improvement in her symptoms within two weeks, leading to a reduction in dosage, and no recurrence or side effects during follow-up, suggesting that baricitinib could be an effective new treatment option for this condition.
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