The Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity. We show here that the small stable furin inhibitor hexa-D-arginine amide effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-D-arginine to PEA-treated mice significantly improves their survival rate and also decreases circulating levels of tumor necrosis factor alpha.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133042 | PMC |
| http://dx.doi.org/10.1128/IAI.70.12.7136-7139.2002 | DOI Listing |
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