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Blarcamesine for the treatment of Early Alzheimer's Disease: Results from the ANAVEX2-73-AD-004 Phase IIB/III trial.
J Prev Alzheimers Dis
January 2025
Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA. Electronic address:
Background: There are no approved oral disease-modifying treatments for Alzheimer's disease (AD).
Objectives: The objective of this study was to assess efficacy and safety of blarcamesine (ANAVEX®2-73), an orally available small-molecule activator of the sigma-1 receptor (SIGMAR1) in early AD through restoration of cellular homeostasis including autophagy enhancement.
Design: ANAVEX2-73-AD-004 was a randomized, double-blind, placebo-controlled, 48-week Phase IIb/III trial.
What does a Trump presidency mean for maternal and infant health in Africa?
Afr J Reprod Health
December 2024
Department of Epidemiology and Population Health, School of Public Health & Information Sciences, University of Louisville, Louisville, Kentucky, USA.
It is sometimes said that when America sneezes, the world catches a cold. The opposite scenario may also apply: a healthy and progressive American economy and democracy provides needed resources and hope to many parts of the world, including Africa. Four years ago, we wrote an optimistic message in this journal.
View Article and Find Full Text PDFArticle Synopsis
- BVA President Liz Mullineaux acknowledges the hectic activities and achievements of 2024.
- She emphasizes the importance of planning and adapting for future challenges.
- Mullineaux expresses optimism and excitement for the opportunities that lie ahead in the upcoming year.
Evaluating the 3-month post-intervention impact of a supportive text message program on mental health outcomes during the 2023 wildfires in Alberta and Nova Scotia, Canada.
Front Public Health
January 2025
Department of Psychiatry, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Article Synopsis
- Individuals exposed to wildfires can develop mental health issues, but supportive text interventions may help mitigate these effects over time.
- The study focused on evaluating a text message support service (Text4Hope) over three months in Alberta and Nova Scotia after the 2023 wildfires, involving participants who completed surveys to assess their mental health before and after the intervention.
- Results indicated significant improvements in wellbeing and reductions in symptoms of depression, anxiety, and PTSD, suggesting the effectiveness of text message support in promoting mental health resilience after disasters.
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