To assess the relationship between antiretroviral drug exposure and lipodystrophy, 69 human immunodeficiency virus type 1-infected patients receiving nelfinavir were investigated cross-sectionally. Lipodystrophy was defined by patients' self-report. Nelfinavir trough concentrations in plasma were significantly related to overall lipodystrophy and peripheral fat wasting scores and appeared to be an independent risk factor for lipodystrophy

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC132744PMC
http://dx.doi.org/10.1128/AAC.46.12.4009-4012.2002DOI Listing

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