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Senolytic Targeting of Anti-Apoptotic Bcl Family Increases Cell Death in UV-Irradiated Senescent Melanocytes: Search for Senolytics.
Exp Dermatol
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Department of Dermatology, Ajou University School of Medicine; Suwon, Suwon, Korea.
Senescent melanocytes have been suggested to play a role in the development of ageing-associated pigmentary changes and skin ageing. Here, we assessed the senolytic capacity of recognised senolytic chemicals and natural compounds in UV-irradiated senescent melanocytes. Among the tested agents, only ABT-737 and ABT-263 showed a significant reduction in the number of SA-β-Gal-positive senescent melanocytes and in the expressions of p16 and p21.
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Department of Medicine, McGill University, Montreal, Canada.
Global, regional, and national burden of young COPD, 1990-2021, with forecasts to 2050: a systematic analysis for the global burden of disease study 2021.
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January 2025
Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Background: Young chronic obstructive pulmonary disease (COPD) refers to people with COPD between the ages of 20 and 50 years. Current epidemiological studies focus on local geography, and there is a lack of global-level analysis. This study provides in-depth analyses of the disease burden of young COPD at global, regional, and national levels.
View Article and Find Full Text PDFSpatial variation and determinants of skilled birth attendant delivery among women of reproductive age in Ethiopia: a spatial and multilevel analysis.
BMC Pregnancy Childbirth
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Department of Public Health, College of Medicine and Health Sciences, Dilla University, Dilla, Ethiopia.
Background: Delivery assisted by skilled birth attendants is essential for maternal and newborn health because most maternal and infant deaths occur during childbirth. Ethiopia continues to use skilled birth care services that are far below acceptable standards. There are also regional variations in skilled birth attendant delivery services in the country.
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Centro Interdisciplinario de Investigaciones Biológicas y Humanas (CIINBIOH), Universidad Autónoma Benito Juárez de Oaxaca (UABJO), Oaxaca, Mexico; R&D Group, Vice Presidency for Scientific Research and Innovation Imam Abdulrahman Bin Faisal University Dammam, Dammam, Saudi Arabia. Electronic address:
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