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The Relationship Between Oxidative Stress and Infertility Due to Antihypertensive Drugs in Rattus Norvegicus.
Animals (Basel)
December 2024
Department of Obstetrics and Gynecology, Ankara University, Ankara 06100, Turkey.
This study aimed to investigate the effect of antihypertensive drugs on reproductive function in Rattus norvegicus and demonstrate the potential role of oxidative stress in reproductive dysfunction. Rattus norvegicus were selected as the experimental animals and divided into the following groups: healthy (control group), clonidine (CL), rilmenidine (RLD), methyldopa (MTL), amlodipine (ALD), and ramipril (RML). Each individual in each group was marked from one to six.
View Article and Find Full Text PDFNot first-line antihypertensive agents, but still effective-The efficacy and safety of imidazoline receptor agonists: A network meta-analysis.
Pharmacol Res Perspect
June 2024
Faculty of Pharmacy, Institute of Clinical Pharmacy, University of Szeged, Szeged, Hungary.
Cardiovascular disorders are the leading cause of death in the world. Many organ diseases (kidney, heart, and brain) are substantially more prone to develop in people with hypertension. In the treatment of hypertension, first-line medications are recommended, while imidazoline receptor agonists are not first-line antihypertensives.
View Article and Find Full Text PDFAnalysis of the nischarin expression across human tumor types reveals its context-dependent role and a potential as a target for drug repurposing in oncology.
PLoS One
May 2024
Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.
Nischarin was reported to be a tumor suppressor that plays a critical role in breast cancer initiation and progression, and a positive prognostic marker in breast, ovarian and lung cancers. Our group has found that nischarin had positive prognostic value in female melanoma patients, but negative in males. This opened up a question whether nischarin has tumor type-specific and sex-dependent roles in cancer progression.
View Article and Find Full Text PDFMELANOMA AND DYSPLASTIC NEVI DEVELOPMENT AFTER RANITIDINE/RILMENIDINE/МOXONIDINE, LERCANIDIPINE, ROSUVASTATIN AND VERAPAMIL/TRANDOLAPRIL - NEW DATA/CASE SERIES. THE POTENTIAL ROLE OF NITROSAMINE/NDSRIS CONTAMINATION IN POLYMEDICATION AS SUBSTANTIAL SKIN CANCER TRIGGERING FACTOR.
Georgian Med News
November 2023
2Department of Dermatology and Venereology, Medical Institute of Ministry of Interior, Sofia, Bulgaria.
Article Synopsis
- - The concept of drug-induced Nitrosogenesis suggests that long-term exposure to nitrosamines in medications may contribute to cancer, particularly melanoma, which has been linked to drugs like Valsartan and Hydrochlorothiazide.
- - Recent studies have detected potential contamination with carcinogenic nitrosamines in newer medications, including Ranitidine and Rosuvastatin, indicating a broader risk linked to a variety of drugs.
- - Researchers emphasize the need for further exploration of nitrosamines' role in drug-related cancer risks, highlighting the necessity for the scientific community to clarify dosage and exposure levels associated with both combination and single medication use.
New anti-aging strategies: a narrative review.
Acta Dermatovenerol Alp Pannonica Adriat
December 2023
Department of Dermatology, School of Medicine, European University Cyprus, Nicosia, Cyprus.
The objective of anti-aging medicine is to decelerate the aging process and mitigate its associated effects, such as susceptibility to cancer, diabetes, and cardiovascular and neurodegenerative diseases. This review provides an overview of the latest advancements in this field, considering both pharmaceutical and non-pharmaceutical approaches. Electronic literature search involved three databases: MEDLINE, Cochrane, and Google Scholar, supplemented by other available literature.
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