Cryptosporidiosis in HIV-infected patients.

J Postgrad Med

Infectious Diseases Unit, Pistoia Hospital, Piazza Giovanni XXIII, 51100, Pistoia, Italy.

Published: January 2003

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Article Synopsis
  • Oral drug absorption, particularly of clofazimine, can be significantly affected by diarrhea associated with infections like cryptosporidiosis in HIV-infected adults.
  • A population pharmacokinetic model using data from a study of 23 participants revealed that severe diarrhea can reduce clofazimine bioavailability by more than sixfold.
  • Understanding these effects is crucial for optimizing dosing regimens to improve treatment outcomes for patients experiencing gastrointestinal issues.
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Background: Microsporidia and Cryptosporidium are obligate intracellular protozoa. These medically important species are recognized as opportunistic organisms in intestinal complications in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome patients.

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The estimated prevalence rate of adults living with HIV infection in MENA is one of the lowest in the world. To date, no data on the genetic characteristics of isolates from HIV/AIDS patients in Algeria were available. This study aimed to identify species and subtype families prevalent in Algerian HIV-infected patients and contribute to the molecular epidemiology mapping of in the MENA region.

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Introduction: infection with Human Immune deficiency Virus (HIV) increases the risk of opportunistic infections, which aggravates life-long complications. We report the prevalence and the associated factors of intestinal parasites among HIV infected clients attending anti-retroviral therapy (ART) clinic at Masaka Regional Referral Hospital, in Uganda.

Methods: this was a cross-sectional study that purposefully enrolled 410 HIV infected clients.

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