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Surgical management of thymic tumors: a narrative review with focus on robotic-assisted surgery.
Mediastinum
November 2024
University of Bern, Bern, Switzerland.
Background And Objective: Thymic epithelial tumors, including thymomas and thymic carcinomas, represent the most common mediastinal tumors and account for up to 50% of all anterior mediastinal tumors. For early stages of these thymic tumors, complete resection of the entire thymus is the recommended treatment. The transition from open surgery to video-assisted thoracoscopic surgery (VATS) and recently to robotic-assisted thoracic surgery (RATS) has fundamentally altered the treatment of thymic tumors.
View Article and Find Full Text PDFA Brief History of Cell Culture: From Harrison to Organs-on-a-Chip.
Cells
December 2024
Department of Genetic, Ribeirão Preto Medical School, University of São Paulo-USP, Ribeirão Preto 14040-904, Brazil.
This comprehensive overview of the historical milestones in cell culture underscores key breakthroughs that have shaped the field over time. It begins with Wilhelm Roux's seminal experiments in the 1880s, followed by the pioneering efforts of Ross Granville Harrison, who initiated groundbreaking experiments that fundamentally shaped the landscape of cell culture in the early 20th century. Carrel's influential contributions, notably the immortalization of chicken heart cells, have marked a significant advancement in cell culture techniques.
View Article and Find Full Text PDFQuantitative Structural Analysis of Hyperchromatic Crowded Cell Groups in Cervical Cytology: Overcoming Diagnostic Pitfalls.
Cancers (Basel)
December 2024
Department of Clinical Laboratory, Shikoku Cancer Center, Matsuyama 791-0245, Japan.
Background: The diagnostic challenges presented by hyperchromatic crowded cell groups (HCGs) in cervical cytology often result in either overdiagnosis or underdiagnosis due to their densely packed, three-dimensional structures. The objective of this study is to characterize the structural differences among HSIL-HCGs, AGC-HCGs, and NILM-HCGs using quantitative texture analysis metrics, with the aim of facilitating the differentiation of benign from malignant cases.
Methods: A total of 585 HCGs images were analyzed, with assessments conducted on 8-bit gray-scale value, thickness, skewness, and kurtosis across various groups.
Lodged Thrombus: A Pitfall for Diagnosing Carotid Web Using Contrast-Angiography.
Cureus
October 2024
Department of Cerebrovascular Medicine, Teine Keijinkai Hospital, Sapporo, JPN.
Carotid web, a form of fibromuscular dysplasia, involves a thin, membrane-like tissue in the carotid bulb that can cause thrombus formation and is linked to cryptogenic ischemic stroke. Diagnosis typically relies on detecting a shelf-like filling defect in digital subtraction angiography or 3D-CT angiography. We report a case of the symptomatic carotid web that could not be diagnosed using DSA or 3D-CT angiography due to a lodged thrombus but was successfully identified through carotid ultrasonography.
View Article and Find Full Text PDFCytologic diagnosis and differential diagnosis of histiocytic signet ring cells in effusion specimens.
Cytojournal
September 2024
Department of Pathology, The Johns Hopkins Hospital, Baltimore, United States.
Article Synopsis
- The study investigates benign histiocytic proliferation in effusions, noting its similarities to diseases like rheumatoid arthritis and lupus, while highlighting potential confusion with malignant tumors.
- Out of 755 benign effusion cases analyzed over a year, 35 cases exhibited histiocytic signet ring cell features, emphasizing the importance of correct diagnosis.
- Key characteristics of these benign histiocytes include clear cytoplasm, eccentric nuclei, and a specific morphology that distinguishes them from malignant cells, confirmed through immunohistochemical staining.
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