Introduction: Lambdoid synostosis can be found unilaterally, bilaterally or in combination with other forms of craniosynostosis. Based on the concept of frontoorbital advancement, we used the occipital advancement in order to correct unilateral or bilateral lambdoid synostosis.
Methods: The standardized technique consists of transverse osteotomies, removal, remodelling and advancement of the occipital region.
Results: Standardized occipital advancement was performed in 21 patients at a multidisciplinary craniofacial centre. The surgery was carried out for patients between 5 and 28 months of age. Aesthetically satisfactory skull shape and normalization of the intracranial pressure could be achieved. A major complication in the form of a life-threatening intraoperative haemorrhage occurred in one case. Other complications like infections have not been experienced.
Conclusion: Standardized occipital advancement allows precise, reproducible and predictable positioning of the segments. Artificial 'sutures' are created as a result of the osteotomy. Remodelling leads to a well-proportioned skull shape and posterior advancement leads to an increase in intracranial volume.
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http://dx.doi.org/10.1054/jcms.2002.0326 | DOI Listing |
Alzheimers Dement
December 2024
Seoul National University Bundang Hospital, Seongnam, Korea, Republic of (South).
Background: To investigate the neuroanatomical characteristics at the whole-brain level associated with progression from amyloid-positive preclinical to prodromal Alzheimer's disease (AD) in relation to amyloid deposition and regional atrophy.
Method: We included 45 participants with amyloid-positive preclinical AD and 135 participants with prodromal AD matched 1:3 by age, sex, and education, from participants in the Korean Longitudinal Study on Cognitive Aging and Dementia and visitors to the dementia clinic of Seoul National University Bundang Hospital. All participants underwent F-florbetaben positron emission tomography and 3D structural T1-weighted magnetic resonance imaging.
Alzheimers Dement
December 2024
Reina Sofia Alzheimer Centre, CIEN Foundation, ISCIII, Madrid, Spain.
Background: About 20-30% of clinically diagnosed AD dementia patients do not meet pathologic criteria for AD and this proportion is even higher in amnestic MCI. Among tau-negative amnestic patients, limbic-predominant age-related TDP-43 encephalopathy (LATE) has been described as a principal diagnostic alternative, especially at advanced age. LATE is characterized by a specific temporo-limbic hypometabolic signature on FDG-PET that may aid in differential diagnosis.
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December 2024
USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Background: Diagnosis of cerebral amyloid angiopathy (CAA) presents a significant challenge in determining whether to propose anti-amyloid treatment plans. The identification of perivascular spaces (PVS) through MRI serves as a possible strategy to elucidate the physiopathological interconnections between the brain's clearance mechanisms and the accumulation of amyloid. This study endeavors to the association between PVS morphology and CAA pathology.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Brigham and Women's Hospital and Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: Virtually all adults with Down Syndrome(DS) show Alzheimer's disease(AD)-related pathologic change by the age of 40 years. While sex differences in Aβ-dependent tauopathy are apparent during early sporadic AD, sex differences in the DS population remain under-investigated. Moreover, menopause onset occurs earlier in the DS population (45 years), and it remains unknown whether menopause status and hormone therapy(HT) exposure influences Aβ-dependent tauopathy in women with DS.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
Background: Rural-dwelling older adults are at increased risk for Alzheimer's disease (AD) and related dementia. Identifying how rural living and neighborhood disadvantage affect neurobiology may help to understand rural-urban disparities in AD and promote healthy aging in rural communities. In this study, we characterize rural-urban differences in cortical thickness (CT), and the association of regional CT with neighborhood disadvantage, using both clinically normal and impaired older adults.
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