We measured persistent Na(+) current and membrane properties of bursting-pacemaker and nonbursting inspiratory neurons of the neonatal rat pre-Bötzinger complex (pre-BötC) in brain stem slice preparations with a rhythmically active respiratory network in vitro. In whole-cell recordings, slow voltage ramps ( g(NaP)/g(Leak) in nonpacemaker cells (P < 0.0002). We conclude that I(NaP) is ubiquitously expressed by pre-BötC inspiratory neurons and that bursting pacemaker behavior within the heterogeneous population of inspiratory neurons is achieved with specific ratios of these two conductances, g(NaP) and g(Leak).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1152/jn.00081.2002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The opioid epidemic is a pervasive health issue and continues to have a drastic impact on the United States. This is primarily because opioids cause respiratory suppression and the leading cause of death in opioid overdose is respiratory failure ( , opioid-induced respiratory depression, OIRD). Opioid administration can affect the frequency and magnitude of inspiratory motor drive by activating µ-opioid receptors that are located throughout the respiratory control network in the brainstem.
View Article and Find Full Text PDFEarly life exposure to deltamethrin impairs synaptic function by altering the brain derived extracellular vesicle proteome.
Mol Cell Proteomics
December 2024
Department of Pharmacology and Toxicology, University of Texas Medical Branch.
Article Synopsis
- Pyrethroid pesticides, particularly deltamethrin (DM), may contribute to neurodevelopmental disorders like ADHD and autism, but the exact mechanisms are still not fully understood.
- The study utilized a rodent model to analyze brain-derived extracellular vesicles (BDEVs) from mice exposed to DM and identified 89 differentially expressed proteins linked to mitochondrial function and synaptic plasticity.
- Ultimately, the research found that BDEVs from DM-exposed mice impaired long-term potentiation (LTP) in hippocampal synapses, suggesting that changes in BDEV signaling play a critical role in the neurotoxic effects of DM.
Hydrogen inhalation exerts anti-seizure effects by preventing oxidative stress and inflammation in the hippocampus in a rat model of kainic acid-induced seizures.
Neurochem Int
December 2024
School of Medicine, Fu Jen Catholic University, New Taipei City, 24205, Taiwan; Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan City, 33303, Taiwan. Electronic address:
Hydrogen gas (H) is an antioxidant with demonstrated neuroprotective efficacy. In this study, we administered H via inhalation to rats to evaluate its effects on seizures induced by kainic acid (KA) injection and the underlying mechanism. The animals were intraperitoneally injected with KA (15 mg/kg) to induce seizures.
View Article and Find Full Text PDFGyosaponin ameliorates sevoflurane anesthesia-induced cognitive dysfunction and neuronal apoptosis in rats through modulation of the PI3K/AKT/mTOR pathway.
Clinics (Sao Paulo)
December 2024
Department of Anesthesia, Central People's Hospital of Zhanjiang, Zhanjiang City, Guangdong Province, PR China. Electronic address:
Background: Sevoflurane (Sev) is an inhalational anesthetic for surgical procedures where it can trigger cognitive dysfunction and neuronal apoptosis. Gyosaponin (GpS) was studied for its effects on brain morphology and cognitive behaviors in Sev-anesthetized rats.
Methods: Male Sprague-Dawley rats were induced by 3 % Sev anesthesia, and 25 mg/kg and 100 mg/kg GpS were injected into the rats by tail vein.
Mechanistic insights into sevoflurane-induced hippocampal neuronal damage and cognitive dysfunction through the NEAT1/Nrf2 signaling axis in aged rats.
Cell Biol Toxicol
December 2024
Department of Anesthesiology, the First Hospital of China Medical University, Shenyang, 110001, Liaoning, People's Republic of China.
The use of anesthetics during surgery can cause severe neurological damage and cognitive dysfunction in elderly patients. However, this health issue currently lacks corresponding therapeutic strategies. This research involved the utilization of single-cell RNA sequencing (scRNA-seq) and transcriptomic assessment to pinpoint crucial cell classifications and molecular pathways, as well as the lncRNA expression profiles, that undergo substantial alterations in aged rats experiencing sevoflurane-induced cognitive impairment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!