A protein-cleaving catalyst specific for a disease-related protein can be used as a catalytic drug. As the first protein-cleaving catalyst selective for a protein substrate, a catalyst for myoglobin was designed by attaching Cu(II) or Co(III) complex of cyclen to a binding site searched by a combinatorial method using peptide nucleic acid monomers as building units. [reaction: see text]
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Synthetic artificial peptidases and nucleases using macromolecular catalytic systems.
Acc Chem Res
July 2003
School of Chemistry and Center for Molecular Catalysis, Seoul National University, Seoul 151-747, Korea.
Effective artificial enzymes have been designed by adopting macromolecular systems for catalyst-substrate complexes. Artificial active sites comprising two or more organic functional groups were built on macromolecular backbones, leading to several types of organic artificial proteases. The activity of metal centers for peptide or DNA hydrolysis was greatly enhanced by attachment to polystyrene, leading to artificial metallopeptidases with substrate selectivity as well as artificial metallonucleases with high catalytic activity for double stranded DNA.
View Article and Find Full Text PDFToward protein-cleaving catalytic drugs: artificial protease selective for myoglobin.
Bioorg Med Chem
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School of Chemistry, Seoul National University, Seoul 151-747, South Korea.
A protein-cleaving catalyst highly selective for a disease-related protein can be used as a catalytic drug. As the first protein-cleaving catalyst selective for a protein substrate, a catalyst for myoglobin (Mb) was designed by attaching the Cu(II) or Co(III) complex of cyclen to a binding site searched by a combinatorial method using peptide nucleic acid monomers as building units. Various linkers were inserted between the catalytic Co(III) center and the binding site of the Mb-cleaving catalyst.
View Article and Find Full Text PDFProtein-cleaving catalyst selective for protein substrate.
Org Lett
November 2002
School of Chemistry and Center for Molecular Catalysis, Seoul National University, Seoul 151-747, Korea.
A protein-cleaving catalyst specific for a disease-related protein can be used as a catalytic drug. As the first protein-cleaving catalyst selective for a protein substrate, a catalyst for myoglobin was designed by attaching Cu(II) or Co(III) complex of cyclen to a binding site searched by a combinatorial method using peptide nucleic acid monomers as building units. [reaction: see text]
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