AI Article Synopsis
- The study examined the susceptibility of 92 mycobacterial strains, including 85 from tuberculosis patients, to varying concentrations of levofloxacin on specific media.
- Approximately 87.8% of the clinical isolates were found to be multi-drug resistant, highlighting a significant challenge in treatment.
- However, 97.8% of the remaining clinical and laboratory strains showed susceptibility to all tested concentrations of levofloxacin, indicating its potential effectiveness against most strains.
Article Abstract
Susceptibility of 92 strains of mycobacteria to levofloxacin (5, 10 and 50 mcg/mL) was investigated by indirect method of absolute concentrations on Levenstain-Jensen media. The investigation was performed on 85 strains of Mycobacterium tuberculosis isolated from 83 patients with different types of tuberculosis and also on drug-sensitive laboratory strains of M. tuberculosis H37Rv-M, H37Rv-GISK, Academia, M. bovis-bovinus 8, M. bovis BCG and on two strains of M. fortuitum with total resistance to antimycobacterial agents. 87.8 per cent of clinical isolates were multi-drug resistant. From one patient treated with ciprofloxacin two strains of M. tuberculosis were isolated--one resistant to 5 mcg/mL of levofloxacin and second strain-resistant to 10 mcg/mL of levofloxacin. All other clinical and laboratory strains of mycobacteria (97.8 per cent) were susceptible to all three concentrations of levofloxacin.
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