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Anagen Effluvium in a Child Misusing Methotrexate: A Case Report With Dermoscopic Findings.
Pediatr Dermatol
March 2025
Department of Dermatology, Ankara Etlik City Hospital, Ankara, Turkey.
Anagen effluvium is a rare adverse effect of methotrexate therapy, generally associated with high-dose regimens. We report a 12-year-old girl who developed abrupt hair loss 1 week after inadvertently taking methotrexate 15 mg daily for five consecutive days (total 75 mg), without other signs of systemic toxicity. Trichoscopic examination and trichogram findings confirmed methotrexate-induced anagen effluvium, and spontaneous hair regrowth occurred after 2 months.
View Article and Find Full Text PDFNew recommendations for reversal of high-dose methotrexate cytotoxicity with folinic acid.
Cancer Chemother Pharmacol
March 2025
Resonance, Memphis, TN, USA.
Purpose: Folinic acid (FA) rescue protocols to counter the adverse effects of high-dose methotrexate (HDMTX) vary widely, and the risk of over-rescue and potential adverse effects of excessive FA (e.g., hypercalcemia) are under-recognized issues when providing augmented rescue in cases of delayed methotrexate elimination (DME).
View Article and Find Full Text PDFAnticancer drugs alter active nitrogen-cycling communities with effects on the nitrogen removal efficiency of a continuous-flow aerobic granular sludge system.
Chemosphere
March 2025
Environmental Microbiology Group, Institute of Water Research, University of Granada, Granada, 18003, Spain; Department of Microbiology, University of Granada, Granada, 18071, Spain.
There is increasing awareness of the presence of anticancer drugs (ACDs) in wastewater. Nonetheless, how ACDs affect the performance of wastewater treatment systems and their microbial populations remains largely unclear. This study investigated the effects of three common ACDs (cyclophosphamide, tamoxifen, and methotrexate) at varying concentrations on physicochemical parameters and drug removal efficiency in an aerobic granular sludge (AGS) system operated in a continuous-flow reactor.
View Article and Find Full Text PDFManagement of Mycosis Fungoides and Sézary Syndrome With Oral Systemic Therapies.
J Cutan Med Surg
March 2025
Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Mycosis fungoides (MF) and Sézary syndrome (SS) are subtypes of cutaneous T-cell lymphoma with numerous topical and systemic therapies. Early-stage MF can be managed with topical corticosteroids, mechlorethamine, and phototherapy. However, patients are often non-responsive to topical therapies, thus requiring systemic therapies.
View Article and Find Full Text PDFAdvances in the treatment of polymyalgia rheumatica.
Rheumatology (Oxford)
March 2025
Department of Rheumatology, Hospital of Bruneck (ASAA-SABES), Teaching Hospital of the Paracelsius Medical University, Brunico, Italy.
Polymyalgia rheumatica (PMR) is a common inflammatory disorder affecting individuals over 50. The cornerstone of PMR treatment remains oral glucocorticoids (GCs), with initial doses tailored to the risk of relapse and comorbidities. However, relapses occur in up to 76% of cases, and long-term GC use is associated with significant toxicity, affecting up to 85% of patients.
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