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Unusual Presentation of Beckwith-Wiedemann Syndrome in an Extremely Low Birth Weight Infant.
Cureus
June 2024
Department of Pediatrics, Bahrain Defense Force Hospital, Royal Medical Services, Riffa, BHR.
Beckwith-Wiedemann syndrome (BWS) is a genetic disorder that affects fetal growth in which those afflicted present with features pertaining to that, such as macrosomia, macroglossia, hemihypertrophy, and abdominal wall defects. This case reports the presentation of an infant diagnosed with BWS who was born with an extremely low birth weight of 980 grams, in contrast to the typical presentation of overgrowth and macrosomia. As a result, reaching a diagnosis of BWS was delayed until the patient reached eight months of age, when other clinical features of BWS, such as hemihypertrophy, became apparent on follow-up visits.
View Article and Find Full Text PDFCost-effectiveness Analysis of Screening Extremely Low Birth Weight Children for Hepatoblastoma Using Serum Alpha-fetoprotein.
J Pediatr
October 2020
Department of Pharmaceutical & Health Economics, School of Pharmacy, Los Angeles, CA; Leonard D. Schaeffer Center for Health Policy & Economics, University of Southern California, Los Angeles, CA.
Objectives: To evaluate the cost-effectiveness of screening children born at extremely low birth weight (ELBW) for hepatoblastoma using serial serum alpha-fetoprotein measurements.
Study Design: We created a decision tree to evaluate the cost effectiveness of screening children born at ELBW between 3 and 48 months of age compared with current standard of care (no screening). Our model used discounted lifetime costs and monetary benefits in 2018 US dollars, based on estimates in the published literature.
The association of hepatoblastoma, prematurity and cerebral palsy: Case reports.
J Pediatr Rehabil Med
June 2021
Department of Pediatric Physical Medicine and Rehabilitation, Shirley Ryan AbilityLab, Chicago, IL, USA.
Purpose: Hepatoblastoma is the most common primary liver tumor in children and has a greater incidence in children with a history of prematurity and very low birth weight. To increase awareness of the association between prematurity and hepatoblastoma for health care providers who treat children with Cerebral Palsy (CP), we present two case reports.
Methods: Two case reports of premature, very low birth weight infants with hepatoblastoma are described and a literature review of hepatoblastoma in the setting of prematurity and cerebral palsy is performed.
Gestational risk factors and childhood cancers: A cohort study in Taiwan.
Int J Cancer
September 2020
Department of Public Health, National Cheng Kung University, Tainan, Taiwan.
Gestational risk factors such as birth weight, gestational age and parity have been repeatedly found to be related to pediatric cancers, but few reports have emerged from Asian countries. Here we report on demographic and gestational factors in a Taiwanese cohort. Our study included all children born in Taiwan 2004-2014 for whom there was a birth record (n = 2,079,037), of which 1900 children had been diagnosed with cancer prior to age 12.
View Article and Find Full Text PDFHepatoblastoma surveillance in infants born with very low birth weight: Has the time come?
J Pediatr
January 2020
Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas.
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