Severity: Warning
Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Subglottic malignancies are rare. They constitute about 1% of laryngeal cancer. Most of these malignancies are squamous cell carcinoma. In this article were describe various definitions concerning the borders of the subglottic region. A summary of pathophysiology and behavior of cancer in this location is presented. The incidence of primary subglottic carcinoma is low. The origin of most cancers in this area is the glottic cancer that extends into the subglottic region. The tumor tends to spread through lymphatic channels to the paraglottic and preglottic (delphian) nodes and secondary to the jugular chain. The delayed diagnosis is due to the lack of symptoms in the early stage of the disease and the hidden location of the tumor. The presenting symptoms are usually dyspnea and stridor. Direct laryngoscopy is essential for early detection of the tumor and the use of CT and MRI is advocated. Therapy is usually radical. Total laryngectomy and radiation therapy have both been advocated. Between 1995 and 2000, 126 patients with laryngeal squamous cell carcinoma were presented to our department. Our experience in diagnosing and treating subglottic cancer in 4 patients is hereby described. The latest literature on the subject is reviewed.
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