It is widely believed that stem cells are the relevant target cells for colonic cell transformation. Evidence is presented that a proliferative transit daughter cell acquiring a mutant adenomatous polyposis coli gene during upward migration from the crypt base can develop retention abnormalities and permanence in the crypt, thus qualifying as a transformed clone which is retained in the colonic epithelium.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/carcin/23.11.1777 | DOI Listing |
Publication Analysis
Top Keywords
migrating colonic
4
colonic crypt
4
crypt epithelial
4
epithelial cells
4
cells primary
4
primary targets
4
targets transformation
4
transformation believed
4
believed stem
4
stem cells
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!