Removal of dihydroxy-terminated components from monomethoxy-terminated poly(ethylene glycol).

Biomaterials

Herman F. Mark Polymer Research Institute, Polytechnic University, Six MetroTech Center, 333 Jay Street, Brooklyn, NY 11201, USA.

Published: January 2003

A preparative method to remove dihydroxy-terminated components in a sample of presumably monomethoxy, monohydroxy-terminated poly(ethylene glycol) (PEG) is presented. Purification of the monomethoxy-terminated component allows one to prepare a diblock copolymer of PEG and poly(lactic acid) (PLLA) free of a PLLA-PEG-PLLA triblock copolymer in various biomedical applications of the copolymer. Efficiency of the purification is compared for high osmotic pressure chromatography (HOPC) and preparative size exclusion chromatography (SEC). In HOPC, various types of porous silica particles, surfaces, solvents, polymer concentrations have been screened for the optimal performance. It was found that HOPC is more efficient than SEC, especially HOPC of 30-40 wt% solutions in water by a column packed with acid-washed controlled pore glass is optimal in producing high-purity fractions.

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0142-9612(02)00323-xDOI Listing

Publication Analysis

Top Keywords

dihydroxy-terminated components
8
polyethylene glycol
8
chromatography hopc
8
removal dihydroxy-terminated
4
components monomethoxy-terminated
4
monomethoxy-terminated polyethylene
4
glycol preparative
4
preparative method
4
method remove
4
remove dihydroxy-terminated
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!