A case is described of a patient with a myocutaneous pectoralis major flap who presented with an oral lesion of focal acantholytic dyskeratosis that was clinically suspicious of recurrent tumour.
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Papular Acantholytic Dyskeratosis of the Vulva: A Case Report and Literature Review.
Clin Cosmet Investig Dermatol
January 2025
Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Papular acantholytic dyskeratosis (PAD) of the vulva is an uncommon benign condition characterized by multiple hyperkeratotic papules in the anogenital region. First described in 1984, PAD belongs to the spectrum of focal acantholytic dyskeratoses and shares histopathological features with Darier disease and Hailey-Hailey disease. Despite its persistence, PAD is benign, requiring only reassurance in many cases.
View Article and Find Full Text PDFAcantholytic Dyskeratotic Acanthoma of the Nail Revealed by a Longitudinal Erythronychia.
Skin Appendage Disord
December 2024
Dermatology Department, Habib Thameur Hospital, "Genodermatoses and Cancers LR12SP03", Tunis, Tunisia.
Introduction: Focal acantholytic dyskeratosis is a distinctive histological pattern first described by Ackerman in 1972, consisting of focal suprabasal clefts in the epidermis and dyskeratotic cells at all levels of the epidermis with hyperkeratosis and parakeratosis. The first case of subungual acantholytic dyskeratosis acanthoma (ADA) was reported in 1990. This subungual variant is a very rare entity.
View Article and Find Full Text PDFDEK::AFF2 Carcinoma of the Sinonasal Tract and Skull Base: A Comprehensive Review.
Surg Pathol Clin
December 2024
Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Taipei City 112201, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Road, Taipei City 112304, Taiwan; Institute of Clinical Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong Road, Taipei City 112304, Taiwan. Electronic address:
DEK::AFF2 carcinoma is an emerging entity of the sinonasal tract and skull base, commonly exhibiting exophytic and endophytic papillary growth, complex anastomosing trabeculae, monotonous cytomorphology, acantholytic change, and tumor-infiltrating neutrophils. A subset displays overt infiltration and high-grade features akin to non-keratinizing squamous cell carcinoma. Glandular differentiation may also be rarely present.
View Article and Find Full Text PDFSOX-10 and Melan-A Immunostaining in Areas of Focal Acantholytic Dyskeratosis and Epidermolytic Hyperkeratosis Within Dysplastic Nevi Biopsies: An Observational Study.
Am J Dermatopathol
January 2025
Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, OH; and.
Background: Focal acantholytic dyskeratosis (FAD) and epidermolytic hyperkeratosis (EHK) are common incidental epidermal histologic findings within dysplastic nevi biopsies. We evaluate whether areas of FAD and EHK within dysplastic nevi biopsies stain with immunostains used to characterize melanocytic neoplasms.
Methods: In this case series, a natural language search of histopathology reports from our institution in the past year (2020-2021) identified dysplastic nevus biopsies with concurrent FAD and/or EHK.
Invasive acantholytic anaplastic extramammary Paget disease: A previously unreported neoplasm in the vulva and review of the literature.
Gynecol Oncol Rep
December 2024
Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Providence, RI 02905, United States.
Article Synopsis
- The report discusses a unique case of invasive acantholytic anaplastic extramammary Paget disease (AAEMPD) found in an 87-year-old woman after multiple treatments for a persistent vulvar lesion.
- Microscopic examination revealed unusual features such as intraepidermal acantholysis and atypical cell growth, raising concerns of both EMPD and invasive carcinoma.
- Accurate diagnosis of AAEMPD is essential as it has different treatment strategies compared to other potential conditions, highlighting the need for careful assessment in clinical practice.
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