Animal models used to study human aging and neurodegeneration do not display all symptoms of these processes as they are found in humans. Recently, we have shown that many cells in neocortical slices from adult human postmortem brain may survive for extensive periods in vitro. Such cultures may enable us to study age and disease related processes directly in human brain tissue. Here, we present observations on subcortical brain tissue.
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http://dx.doi.org/10.1111/j.1582-4934.2002.tb00522.x | DOI Listing |
Genes Chromosomes Cancer
January 2025
Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.
Mature aggressive B-cell lymphomas, such as Burkitt lymphoma (BL) and Diffuse large B-cell lymphoma (DLBCL), show variations in microRNA (miRNA) expression. The entity of High-grade B-cell lymphoma with 11q aberration (HGBCL-11q) shares several biological features with both BL and DLBCL but data on its miRNA expression profile are yet scarce. Hence, this study aims to analyze the potential differences in miRNA expression of HGBCL-11q compared to BL and DLBCL.
View Article and Find Full Text PDFJ Forensic Sci
January 2025
Department of Entomology, Texas A&M University, College Station, Texas, USA.
The house fly, Musca domestica, L. (Diptera: Muscidae), is a filth fly that is often associated with criminal and civil investigations surrounding abuse, neglect, and death of humans and other vertebrates. However, development data, which are crucial for determining the age of immatures collected under forensically relevant circumstances, are limited.
View Article and Find Full Text PDFEpidemiol Psychiatr Sci
January 2025
Department of Global Public Health, Karolinska Institute, Stockholm, Sweden.
Aims: Although individuals with lower socio-economic position (SEP) have a higher prevalence of mental health problems than others, there is no conclusive evidence on whether mental healthcare (MHC) is provided equitably. We investigated inequalities in MHC use among adults in Stockholm County (Sweden), and whether inequalities were moderated by self-reported psychological distress.
Methods: MHC use was examined in 31,433 individuals aged 18-64 years over a 6-month follow-up period, after responding to the General Health Questionnaire-12 (GHQ-12) in 2014 or the Kessler Six (K6) in 2021.
Palliat Support Care
January 2025
Faculdade de Medicina da Universidade de Coimbra, Universidade de Coimbra, Coimbra, Portugal.
One of the most crucial stages of palliative care is the last days and hours of life, which require special attention and knowledgeable identification of clinical signs described as signs of impending death (SID). Our case series of 11 patients receiving home palliative care describes bilateral hypoactive, stereotyped upper arm movements (scratching of the head, forehead, and nose) that were previously unknown or described, often accompanied by SID.
View Article and Find Full Text PDFAfr J Prim Health Care Fam Med
December 2024
Department of Nursing, Faculty of Science, Agriculture and Engineering, University of Zululand, Kwadlangezwa.
Background: According to the United Nations Fund for Population Activities, sexuality education (SE) requires building a multisectoral team and developing an operational plan. Hence, teaching comprehensive sexuality education (CSE) in collaboration with relevant stakeholders is a managerial approach to provide school-going adolescents with the knowledge and skills to make informed decisions that will safeguard their health.
Aim: To report on Life Orientation (LO) teachers' perspectives on intersectoral collaboration management of SE in secondary schools in KwaZulu-Natal (KZN) province, South Africa.
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