AI Article Synopsis
- Chlamydia pneumoniae DNA was found in over 40% of arteries affected by atherosclerosis, alongside other microorganisms.
- Researchers used PCR techniques to analyze 32 diseased artery specimens for DNA from 7 oro-dental and 2 nonoral bacteria.
- Of the specimens, 31.2% tested positive for specific bacteria, highlighting potential complications for antibiotic treatments aimed at Chlamydia pneumoniae in coronary heart disease.
Article Abstract
Chlamydia pneumoniae DNA has been detected in at least 40% of all major arteries affected by atherosclerosis, but several other microorganisms have also been detected. In this study, diseased vessels were evaluated for the presence of the DNA of seven oro-dental bacteria and two nonoral bacteria. A polymerase chain reaction technique was employed using primer pairs based on 16S rRNA genes. Of 32 specimens tested, 10 (31.2%) were DNA positive: seven for Actinobacillus actinomycetemcomitans and three for Prevotella intermedia. The DNA was found in specimens from the aorta and the iliac, internal mammary and coronary arteries. Eleven (35.4%) of 31 specimens had been shown previously to be positive for Chlamydia pneumoniae DNA. A mixture of chlamydiae and oro-dental bacteria was found in three cases. These findings may have implications for antibiotic prophylaxis of coronary heart disease if directed solely at Chlamydia pneumoniae.
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| http://dx.doi.org/10.1007/s10096-002-0810-5 | DOI Listing |
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