This report presents an attempt to adapt the method of study of the cytotoxic effect of streptomycin (SM) for evaluation of its local irritant properties. The cytotoxic effect of streptomycin was treated on bull spermatoza according to Dumitrescu (1). Ten series of SM produced by Tarchomin Pharmaceutical Producers, and international standard streptomycin (Is -- SM) were used in the experiments. The effect of the mentioned substances was checked in isotonic solutions (in 5% glucose containing 0.82, 2.46, 7.38 mg SM base in 1 ml at pH 4.5--4.8). Is -- SM did not show any spermicidal effect, on the contrary, it significantly prolonged the life-span of spermatozoa. The checked series showed statistically significant spermicidal activity. The cytotoxic effect of SM is proportional to its concentration, and varies in particular series. The studied series can be divided into those of strong, moderate, and weak spermicidal activity. The comparison of these results with those of simultaneous clinical and histopathological studies indicates no correlation between the local irritating effect observed in humans, and the cytotoxic influence determined in the test with spermatozoa. The method of study of SM on spermatozoa is unsuitable for evaluation of the local irritating activity of this substance.
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