It was found that the human (hu) myeloma IgG1 Ser, its Fcgamma fragment and the chimeric mouse-human monoclonal antibody (chim-mAb), containing the constant part of hu-gamma1-chain, can exist in a long-term metastable conformational state. This state arises as a result of short incubation of IgG molecules and their Fcgamma fragments at pH<2.8 and the consequent rapid neutralisation to pH 7.0-8.0. At pH<2.8 the three-dimensional structure of C(gamma)2 domains is unfolded, but rapidly refolds after neutralisation. At the same time, non-covalent interactions between C(gamma)2 and C(gamma)3 domains are restored very slowly. A metastable state of IgG keeps 70% of complement-binding ability in comparison with the native state.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0165-2478(02)00203-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cascades Towards Noise-Induced Transitions on Networks Revealed Using Information Flows.
Entropy (Basel)
December 2024
Institute of Informatics, University of Amsterdam, 1098 XH Amsterdam, The Netherlands.
Complex networks, from neuronal assemblies to social systems, can exhibit abrupt, system-wide transitions without external forcing. These endogenously generated "noise-induced transitions" emerge from the intricate interplay between network structure and local dynamics, yet their underlying mechanisms remain elusive. Our study unveils two critical roles that nodes play in catalyzing these transitions within dynamical networks governed by the Boltzmann-Gibbs distribution.
View Article and Find Full Text PDFThe sp Hybridization of Tin Single Atoms for Dendrite-Free Sodium Metal Batteries.
Adv Mater
January 2025
State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.
Restricting the growth of sodium (Na) dendrites at the atomic level is the premise to enable both the stability and safety of sodium metal batteries (SMBs). Here, the universal synthesis of the fourth main group element (Sn, Ge, Pb) as single metal atoms anchored on graphene (Sn, Ge, Pb SAs/G) with sp hybridization for dendrite-free sodium metal anode is reported. The in situ real-time observation of Na growth on Sn SAs/G uncoils a kinetically uniform planar deposition at the atomic level for substantially suppressing the dendrite growth.
View Article and Find Full Text PDFA multifunctional quasi-solid-state polymer electrolyte with highly selective ion highways for practical zinc ion batteries.
Nat Commun
January 2025
State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
The uncontrolled dendrite growth and detrimental parasitic reactions of Zn anodes currently impede the large-scale implementation of aqueous zinc ion batteries. Here, we design a versatile quasi-solid-state polymer electrolyte with highly selective ion transport channels via molecular crosslinking of sodium polyacrylate, lithium magnesium silicate and cellulose nanofiber. The abundant negatively charged ionic channels modulate Zn desolvation process and facilitate ion transport.
View Article and Find Full Text PDFHippocampus encoding memory engrams as stable heteroclinic network.
Chaos
December 2024
School of Mathematics and Statistics, Northwestern Polytechnical University, Xi'an 710129, China.
Article Synopsis
- The brain's transient activity is illustrated through stable heteroclinic channels (SHCs), which represent pathways of memory formation in its dynamic models, with saddle points symbolizing states of brain activity stability.
- The study builds on a model of hippocampal synaptic networks, showing how short-term memories are transformed into long-term memories as trajectories within these channels, affected by neurotransmitter regulation.
- Numerical findings highlight that while noise can disrupt memory clarity, it also aids in the long-term encoding process, providing a dynamic perspective on how memories are structured and retained.
Long-living transients in ecological models: Recent progress, new challenges, and open questions.
Phys Life Rev
December 2024
School of Computing and Mathematical Sciences, Institute for Environmental Futures, University of Leicester, LE1 7RH, UK; Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Str., 117198 Moscow, Russia. Electronic address:
Traditionally, mathematical models in ecology placed an emphasis on asymptotic, long-term dynamics. However, a large number of recent studies highlighted the importance of transient dynamics in ecological and eco-evolutionary systems, in particular 'long transients' that can last for hundreds of generations or even longer. Many models as well as empirical studies indicated that a system can function for a long time in a certain state or regime (a 'metastable regime') but later exhibits an abrupt transition to another regime not preceded by any parameter change (or following the change that occurred long before the transition).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!