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Self-Healable, Antimicrobial and Conductive Hydrogels Based on Dynamic Covalent Bonding with Silver Nanoparticles for Flexible Sensor.
Polymers (Basel)
December 2024
Chongqing Academy of Metrology and Quality Inspection, Chongqing 401120, China.
Dynamic hydrogels have attracted considerable attention in the application of flexible electronics, as they possess injectable and self-healing abilities. However, it is still a challenge to combine high conductivity and antibacterial properties into dynamic hydrogels. In this work, we fabricated a type of dynamic hydrogel based on acylhydrazone bonds between thermo-responsive copolymer and silver nanoparticles (AgNPs) functionalized with hydrazide groups.
View Article and Find Full Text PDF3D Printing of a Self-Healing, Bioactive, and Dual-Cross-Linked Polysaccharide-Based Composite Hydrogel as a Scaffold for Bone Tissue Engineering.
ACS Appl Bio Mater
January 2025
Advanced Magnetic Materials Research Center, School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, North Kargar Street, Tehran 11155-4563, Iran.
Although 3D printing is becoming a dominant technique for scaffold preparation in bone tissue engineering (TE), developing hydrogel-based ink compositions with bioactive and self-healing properties remains a challenge. This research focuses on developing a bone scaffold based on a composite hydrogel, which maintains its self-healing properties after incorporating bioactive glass and is 3D-printable. The plain hydrogel ink was synthesized using natural polymers of 1 wt % N-carboxyethyl chitosan, 2 wt % hyaluronic acid aldehyde, 0.
View Article and Find Full Text PDFAnti-inflammatory dressing based on hyaluronic acid and hydroxyethyl starch for wound healing.
Int J Biol Macromol
December 2024
School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, PR China. Electronic address:
Eliminating persistent inflammation and choosing dressings that provide the best healing environment is key to promoting wound healing. Dynamic and reversible hydrogels have attracted much attention because of their capacity to adapt to irregular wound surfaces. Herein, oxidized hydroxyethyl starch (OHES) and hyaluronic acid (HA-ADH) were crosslinked via the dynamic acylhydrazone bond to form an anti-inflammatory function hydrogel (HA-ADH/OHES@XT) that could release xanthatin (XT) slowly.
View Article and Find Full Text PDFTarget-Directed Dynamic Combinatorial Chemistry Affords Binders of IspE.
ACS Omega
September 2024
Saarland University, Department of Pharmacy, Campus Building E8.1, 66123 Saarbrücken, Germany.
In the search for new antitubercular compounds, we leveraged target-directed dynamic combinatorial chemistry (tdDCC) as an efficient hit-identification method. In tdDCC, the target selects its own binders from a dynamic library generated , reducing the number of compounds that require synthesis and evaluation. We combined a total of 12 hydrazides and six aldehydes to generate 72 structurally diverse -acylhydrazones.
View Article and Find Full Text PDFExploring the anticancer potential of new 3-cyanopyridine derivatives bearing N-acylhydrazone motif: Synthesis, DFT calculations, cytotoxic evaluation, molecular modeling, and antioxidant properties.
J Biochem Mol Toxicol
September 2024
Laboratory of Synthesis of Molecules with Biological Interest, University of Constantine 1, Constantine, Algeria.
3-Cyanopyridine derivatives are known for exhibiting excellent anticancer activity due to their strong capability to inhibit various biological targets, including Pim-1 kinase, survivin, and tubulin polymerization. On the other hand, N-acylhydrazones (NAH) are known to be a very versatile motif in medicinal chemistry and drug design. Based on these data, we report in this paper, the synthesis of novel 3-cyanopyridines incorporating N-acyl hydrazine scaffold, the evaluation of their cytotoxicity on the breast (MCF-7) and ovarian (A-2780) cancer cell lines and their antioxidant properties.
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