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Mandating chaperones for decision making in left atrial appendage occlusion is bad for patients, for physicians, and for the promotion of real shared decision making: It's time to end the Centers For Medicare Medicaid Services chaperone mandate.
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Anti-Ku + myositis: an acquired inflammatory protein-aggregate myopathy.
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Department of Neuropathology, Charité. Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
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Sanglifehrin A mitigates multiorgan fibrosis by targeting the collagen chaperone cyclophilin B.
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Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Pathological deposition and crosslinking of collagen type I by activated myofibroblasts drives progressive tissue fibrosis. Therapies that inhibit collagen synthesis have potential as antifibrotic agents. We identify the collagen chaperone cyclophilin B as a major cellular target of the natural product sanglifehrin A (SfA) using photoaffinity labeling and chemical proteomics.
View Article and Find Full Text PDFInhibition of autophagy prevents cardiac dysfunction at early stages of cardiomyopathy in Bag3-deficient hearts.
J Mol Cell Cardiol
August 2024
Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.; The German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main.. Electronic address:
The HSP70 co-chaperone BAG3 targets unfolded proteins to degradation via chaperone assisted selective autophagy (CASA), thereby playing pivotal roles in the proteostasis of adult cardiomyocytes (CMs). However, the complex functions of BAG3 for regulating autophagy in cardiac disease are not completely understood. Here, we demonstrate that conditional inactivation of Bag3 in murine CMs leads to age-dependent dysregulation of autophagy, associated with progressive cardiomyopathy.
View Article and Find Full Text PDFUnveiling the genetic tapestry: Rare disease genomics of spinal muscular atrophy and phenylketonuria proteins.
Int J Biol Macromol
June 2024
Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA. Electronic address:
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