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| http://dx.doi.org/10.1136/bmj.325.7371.1033/a | DOI Listing |
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LD-transpeptidase-mediated cell envelope remodeling enables developmental transitions and survival in and .
J Bacteriol
January 2025
Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, New York, USA.
and are two phylogenetically related bacterial pathogens that exhibit extreme intrinsic resistance when they enter into a dormancy-like state. This enables both pathogens to survive extended periods in growth-limited environments. Survival is dependent upon their ability to undergo developmental transitions into two phenotypically distinct variants, one specialized for intracellular replication and another for prolonged survival in the environment and host.
View Article and Find Full Text PDFOccurrence of macrolides resistance in Legionella pneumophila ST188: results of the Belgian epidemiology and resistome investigation of clinical isolates.
Int J Infect Dis
January 2025
National reference centre for Legionella pneumophila, Department of Microbiology, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Laarbeeklaan 101, 1090 Brussels, Belgium.
Introduction: The incidence of Legionnaires' disease (LD) steadily increases worldwide. Although Legionella pneumophila is known as pathogenic, systematic investigations into antibiotic resistance are scarce, and reports of resistance in isolates are recently emerging.
Methods: Clinical cases and metadata reported to the Belgian National Reference Centre between 2011 and 2022 were retrospectively analysed.
Scoping review of infectious disease prevention, mitigation and management in passenger ships and at ports: mapping the literature to develop comprehensive and effective public health measures.
Trop Med Health
January 2025
Laboratory of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, 22 Papakyriazi Street, 41222, Larissa, Thessaly, Greece.
Background: With various infectious disease risks to passenger ship travellers, guidance for infectious disease prevention, mitigation and management (PMM) exists. Emerging infections and emergencies necessitate updated, context-specific guidelines and practices. New evidence for infection PMM must be translated into guidance for governmental authorities and the passenger ship industry.
View Article and Find Full Text PDFLaying the groundwork for a risk management program for public drinking water systems.
J Water Health
December 2024
Environmental Science, Policy and Research Institute, 144 Narberth Ave, Box 407, Narberth, PA 19072, USA.
is different from traditional drinking water contaminants because it presents a latent public health risk for public and private drinking water systems and for the building water systems they supply. This paper reviews information on the likelihood of occurrence of in public water systems to lay a foundation for public water systems, as a stakeholder in public health risk management, to better manage . Important to this approach is a literature review to identify conditions that could potentially promote being present in drinking water systems at either an elevated abundance or at an increased frequency of occurrence, and/or water quality and supply conditions that would contribute to its amplification.
View Article and Find Full Text PDFThe Burr distribution as a model for the delay between key events in an individual's infection history.
PLoS Comput Biol
December 2024
Department of Mathematics, University of Manchester, Manchester, United Kingdom.
Understanding the temporal relationship between key events in an individual's infection history is crucial for disease control. Delay data between events, such as infection and symptom onset times, is doubly censored because the exact time at which these key events occur is generally unknown. Current mathematical models for delay distributions are derived from heuristic justifications.
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