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Myeloid-specific deletion of autotaxin inhibits rheumatoid arthritis and osteoclastogenesis.
Front Immunol
January 2025
Department of Pharmacy, College of Pharmacy, Pusan National University, Busan, Republic of Korea.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint swelling, pain, and bone remodeling. We previously reported that autotaxin (ATX) deficiency disrupts lipid rafts in macrophages. Lipid raft disruption results in the dysregulation of RANK signaling, which is crucial for osteoclastogenesis and the pathogenesis of RA.
View Article and Find Full Text PDFSurgical Management of Radial Head and Proximal Ulna Fractures Without Elbow Dislocation: A Case Report.
Cureus
December 2024
Orthopedics and Traumatology, Istanbul University-Cerrahpasa, Istanbul, TUR.
Fractures involving the proximal ulna and radial head are common injuries that occur in the upper extremity, often resulting from traumatic incidents such as falls or direct impact. The proximal ulna forms the elbow joint with the humerus, while the radial head articulates with both the humerus and the ulna, facilitating forearm rotation. Fractures in these areas can disrupt the stability and function of the elbow joint, leading to pain, swelling, and limited range of motion.
View Article and Find Full Text PDFResults of treating patients with cellulitis by hyperbaric oxygen: a case-control study.
Int Marit Health
January 2025
Institute of Maritime Medicine, Hai Phong, Vietnam, 21 Vo Nguyen Giap, Le Chan, Kenh Duong, Hai Phong, Vietnam, 18000 Hai Phong, Viet Nam.
Background: Cellulitis is an acute bacterial infection of the skin and subcutaneous tissue. The characteristic symptoms of the disease are an area of skin that is swollen, warmth, redness, pain, unknown borderline, tends to expand, and can lead to tissue necrosis. Hyperbaric Oxygen (HBO) is a non-drug treatment, which has the effect of relieving pain, reducing edema, and accelerating the wound healing process for patients with cellulitis.
View Article and Find Full Text PDFPedicle ossification following mandibular reconstruction using fibular free flap in a patient with osteoradionecrosis of the jaw: a case report.
J Korean Assoc Oral Maxillofac Surg
December 2024
Oral Oncology Clinic, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
Pedicle ossification is a rare but significant complication following mandibular reconstruction using a fibular free flap (FFF), a technique widely employed in maxillofacial surgery due to its reliable vascularized bone supply and low donor site morbidity. The FFF supports dental implantation and prosthetic rehabilitation, with its vascularized periosteum enhancing osteogenic potential. Despite these advantages, unexpected ossification of the flap's vascular pedicle may occur, potentially mimicking tumor recurrence and causing diagnostic uncertainty.
View Article and Find Full Text PDFSimultaneous bilateral deep femoral artery aneurysms: case report of a rare peripheral arterial aneurysm.
J Surg Case Rep
January 2025
Department of Surgery, College of Health Sciences, Addis Ababa University, 1000 Addis Ababa, Ethiopia.
Deep femoral artery aneurysms are very rare; particularly when isolated and occur simultaneously in both limbs. We report such a case of a misdiagnosed 16-year-old male presenting after hematoma evacuation was attempted for painful swelling in the left groin. Once the diagnosis was confirmed by computed tomography angiography (CTA), an emergency aneurysmectomy with deep femoral artery (DFA) ligation was performed on the left limb.
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