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The effect of the hormone-like estrogen-progestagen preparation megestranol and of megestranol-spasmolytin combination on the activity of metabolic processes in the uterine mucous membrane was studied in experiments on rats. Results of cytochemical studies showed megestranol and megestranol-spasmolytin combination to change the metabolic activity of the uterine mucous membrane resulting in a decrease in the RNA content in the epithelial cells of the endometrial glands, thereby creating conditions preventing normal implantation and development of the fertilized ovum.
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