There is evidence that in human Pavlovian conditioning positive patterning (A-, B-, AB+) as well as negative patterning (A+, B+, AB-) are solved by applying abstract rules. In the present report we further investigated how humans solve patterning discriminations by conducting two Go/NoGo reaction time experiments that utilized the stimulus probability effect: stimuli presented with a low probability of occurrence elicit larger pupil dilations than those presented with a high frequency. In decreasing the ratio of compound and elemental trials from 1/1 (24 A, 24 B, 48 AB) in Experiment 1 to 1/2 (32 A, 32 B, 32 AB) in Experiment 2 we manipulated stimulus probability. The results of both experiments indicate that humans utilize distinctive features such as number information in order to classify the stimuli.
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http://dx.doi.org/10.1016/s0301-0511(02)00088-1 | DOI Listing |
Int J Colorectal Dis
January 2025
Department of Pathomorphology, Medical University of Gdańsk, Gdańsk, Poland.
Purpose: Liver and lung metastases demonstrate distinct biological, particularly immunological, characteristics. We investigated whether preoperative complete blood count (CBC) parameters, which may reflect the immune system condition, predict early dissemination to the liver and lungs in colorectal cancer (CRC).
Methods: In this retrospective single-centre study, we included 268 resected CRC cases with complete 2-year follow-up and analysed preoperative CBC for association with early liver or lung metastasis development.
Anal Chem
January 2025
Chinese Academy of Inspection and Quarantine, Beijing 100176, China.
Developing ambient ionization methods for direct mass spectrometry (MS) analysis is crucial for achieving sample-to-answer capabilities, especially for rapid analysis and monitoring in specific scenarios. Herein, a compact device is presented that utilizes mesh-collision microtube plasma (MC-μTP) ionization for direct online MS analysis. This device features a self-aspirating design that enables the direct analysis of various sample types.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Department of Physics, Indian Institute of Science, Bangalore 560012, India.
The quest for anisotropic superconductors has been a long-standing pursuit due to their potential applications in quantum computing. In this regard, experimentally, d-wave and anisotropic s-wave superconducting order parameters are predominantly observed, while p-wave superconductors remain largely elusive. Achieving p-wave superconductivity in topological phases is highly desirable, as it is considered suitable for creating topologically protected qubits.
View Article and Find Full Text PDFmBio
January 2025
Analytical Biochemistry and Proteomics Unit, Instituto de Investigaciones Biológicas Clemente Estable and Institut Pasteur de Montevideo, Montevideo, Uruguay.
Unlabelled: Mycobacteria, including pathogens like , exhibit unique growth patterns and cell envelope structures that challenge our understanding of bacterial physiology. This study sheds light on FhaA, a conserved protein in , revealing its pivotal role in coordinating cell envelope biogenesis and asymmetric growth. The elucidation of the FhaA interactome in living mycobacterial cells reveals its participation in the protein network orchestrating cell envelope biogenesis and cell elongation/division.
View Article and Find Full Text PDFACS Nano
January 2025
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California 92093, United States.
The structure and dynamics of water at charged graphene interfaces fundamentally influence molecular responses to electric fields with implications for applications in energy storage, catalysis, and surface chemistry. Leveraging the realism of the MB-pol data-driven many-body potential and advanced path-integral quantum dynamics, we analyze the vibrational sum frequency generation (vSFG) spectrum of graphene/water interfaces under varying surface charges. Our quantum simulations reveal a distinctive dangling OH peak in the vSFG spectrum at neutral graphene, consistent with recent experimental findings yet markedly different from those of earlier studies.
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