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Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression.
Brain Behav Immun Health
February 2025
Dept of Immunology, Erasmus Medical Center, Rotterdam, the Netherlands.
Background: A considerable proportion (21%) of patients with common variable immunodeficiency (CVID) suffers from depression. These subjects are characterized by reduced naïve T cells and a premature T cell senescence similar to that of patients with major depressive disorder (MDD). It is known that T cells are essential for limbic system development/function.
View Article and Find Full Text PDFThymic and T-cell intrinsic critical roles associated with Severe Combined Immunodeficiency and Omenn syndrome due to a heterozygous variant (G201R) in PSMB10.
J Allergy Clin Immunol
December 2024
Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address:
Background: Heterozygous immunoproteasome subunit beta-type 10 (PSMB10) mutations can cause severe combined immunodeficiency (SCID) and Omenn syndrome (OS). Hematopoietic stem cell transplantation in these patients is associated with severe complications and poor immune reconstitution, often resulting in death.
Objective: To perform immunological and molecular characterization of an infant with a PSMB10 heterozygous variant.
Evidence of sex differences in ozone-induced oxysterol and cytokine levels in differentiated human nasal epithelial cells.
Am J Physiol Lung Cell Mol Physiol
February 2025
Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, North Carolina, United States.
Acute exposure to ozone (O) causes upper and lower airway inflammation. We and others have previously demonstrated that O oxidizes lipids, particularly cholesterol, into electrophilic oxysterols, such as secosterol B (SecoB), which can adduct proteins, thus altering cellular signaling pathways. To investigate how O-derived oxysterols influence cytokine and chemokine release, nasal epithelial cells (HNECs) from healthy donors ( = 18 donors) were exposed to 0.
View Article and Find Full Text PDFChanges in senescence markers after a weight loss intervention in older adults with obesity.
Arch Gerontol Geriatr
February 2025
Division of Geriatric Medicine and Center for Aging and Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Article Synopsis
- - The study investigates how weight loss affects aging-related biological markers (specifically SASP) in older adults with obesity, using a six-month telemedicine weight loss program for participants aged 65 and older with a BMI of 30 kg/m or more.
- - Participants who successfully lost at least 5% of their body weight showed significant improvements in physical function and other health markers, with specific SASP cytokines showing strong associations with their outcomes.
- - The results suggest that intentional weight loss may enhance functional abilities in older adults, but further research with randomized trials is needed to confirm these findings and explore additional biomarkers.
Syringic acid improves cyclophosphamide-induced immunosuppression in a mouse model.
Biochem Biophys Res Commun
November 2024
Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Khyber Pakhtunkhwa, Pakistan.
Syringic acid (SA), a naturally occurring phenolic substance present in many edible plants and fruits, has been shown to have potential in immunoenhancement applications. In this study, we investigated the immunomodulatory effects of SA in mitigating cyclophosphamide (CYP)-induced immunosuppression in BALB/c mice using doxycycline as a positive control. SA administration prevented immune organ atrophy and morphological changes in the thymus, spleen, and bone marrow induced by CYP treatment in mice while also showing a dose-dependent enhancement of thymus and spleen indices compared to mice treated with CYP alone.
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