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Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease.
Brain Commun
January 2025
Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.
The largest risk factor for dementia is age. Heterochronic blood exchange studies have uncovered age-related blood factors that demonstrate 'pro-aging' or 'pro-youthful' effects on the mouse brain. The clinical relevance and combined effects of these factors for humans is unclear.
View Article and Find Full Text PDFStiffening symphony of aging: Biophysical changes in senescent osteocytes.
Aging Cell
December 2024
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Senescent osteocytes are key contributors to age-related bone loss and fragility; however, the impact of mechanobiological changes in these cells remains poorly understood. This study provides a novel analysis of these changes in primary osteocytes following irradiation-induced senescence. By integrating subcellular mechanical measurements with gene expression analyses, we identified significant, time-dependent alterations in the mechanical properties of senescent bone cells.
View Article and Find Full Text PDFTopical Platelet Exosomes Reduce Senescence Signaling in Human Skin: An Exploratory Prospective Trial.
Dermatol Surg
November 2024
Center for Regenerative Biotherapeutics, Mayo Clinic, Rochester, Minnesota.
Background: Cellular senescence, an irreversible cell cycle arrest with secretory phenotype, is a hallmark of skin aging. Regenerative exosome-based approaches, such as topical human platelet extract (HPE), are emerging to target age-related skin dysfunction.
Objective: To evaluate the cellular and molecular effects of topical HPE for skin rejuvenation after 12 weeks of twice daily use.
Update on Platelet-Rich Plasma and Platelet-Rich Fibrin for Dermatologic Surgery: Addressing Knowns and Unknowns.
Dermatol Surg
November 2024
Aesthetx Plastic Surgery and Dermatology, Campbell, California.
Article Synopsis
- Autologous and allogeneic platelet-rich plasma (PRP) and its derivatives are widely used in various medical fields but face challenges in cosmetic dermatology due to lack of expert consensus and standardized protocols.
- * A literature review focusing on recent data highlights the efficacy of PRP and PRF in dermatology for applications like wound care and facial rejuvenation.
- * Understanding the differences in preparation, outcomes, and administration timing is crucial for effectively incorporating PRP into dermatologic practices.
GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology.
JCI Insight
August 2024
Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
Article Synopsis
- Malattia Leventinese/Doyne honeycomb retinal dystrophy (ML/DHRD) is a form of retinal degeneration linked to a specific genetic mutation in the fibulin-3 protein, similar to age-related macular degeneration (AMD).
- Researchers developed a method to track fibulin-3 levels in retinal cells and found that the GSK3 inhibitor CHIR99021 effectively reduced its production and altered cell behavior.
- In tests on mice with the ML/DHRD mutation, CHIR treatment significantly decreased harmful structures associated with the disease, suggesting its potential for treating AMD and similar retinal disorders.
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