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Background: Convergent evidence indicates that deficits in the endosomal recycling pathway underlies pathogenesis of Alzheimer's disease (AD). SORL1 encodes the retromer-associated receptor SORLA that plays an essential role in recycling of AD-associated cargos such as the amyloid precursor protein and the glutamatergic AMPA receptor. Importantly, loss of function pathogenic SORL1 variants are associated with AD.
View Article and Find Full Text PDFBackground: Seizures in Alzheimer's Disease (AD) are increasingly recognized to occur and can increase cognitive decline and reduce survival compared to unaffected age-matched peers (Lyou et al. 2018). Administration of antiseizure medicines (ASMs) to AD patients with epileptiform activity may improve cognition (Vossel et al.
View Article and Find Full Text PDFDrug Development.
Alzheimers Dement
December 2024
Mashhad University of Medical Sciences, Mashhad, Razavi Khorasan, Iran (Islamic Republic of).
Background: Microbiota of the distal part of the intestine produces Urolithin A (Uro A) as a derivative of ellagitannins hydrolysis. Recently, the mitophagy, anti-inflammatory, and antioxidant properties of Uro A have focused more attention on its probable beneficial effects on neurodegenerative states. The purpose of this research was to study the impact of Uro A on the histopathology of the cerebellum in a rat model of streptozotocin-induced Alzheimer's disease.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
New York University, New York, NY, USA.
Background: Despite technology adoption and increased dependence on digital technologies, the digital divide persists among older adults. The purpose of this study was to understand barriers and facilitators of recruiting non-English speaking older individuals who are cognitively impaired along with their caregivers for PLAN, an ongoing RCT designed to promote the transition of Korean American older adults with probable dementia and their caregivers into the healthcare system for adequate diagnostic follow-up and care. We also examined online-based recruitment strategies focused on older adults reported in relevant published studies to compare with our experiences.
View Article and Find Full Text PDFDementia Care Practice.
Alzheimers Dement
December 2024
Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Background: Annual cognitive screening in older adults is essential for early detection of cognitive impairment, yet less than half of cases are detected in primary care. We introduce two innovative app-based screeners that help overcome barriers to routine cognitive screening. MyCog is a tablet app that is self-administered in person during the rooming process for a primary care visit (Figure 1).
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