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Deployment to bases with open burn pits and mortality of US Military Veterans.
Occup Environ Med
February 2025
Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA.
Introduction: Five million US Veterans had possible exposure to open burn pits used for waste disposal through service in Iraq (2003-2011) and Afghanistan (2001-2014). Burn pits generate toxic exposures that may be associated with adverse health outcomes. We examined all-cause and cause-specific mortality in relation to deployment to bases with open burn pits.
View Article and Find Full Text PDFMetabolomic profiles of infants classified as sudden infant death syndrome: a case-control analysis.
EBioMedicine
January 2025
Department of Public Health Sciences, University of Virginia, School of Medicine, Charlottesville, VA, USA; Department of Family Medicine, University of Virginia, School of Medicine, Charlottesville, VA, USA.
Background: Sudden Infant Death Syndrome (SIDS) is a leading cause of postneonatal mortality. The absence of specific biomarkers of SIDS diagnosis and risk leaves a significant gap in understanding SIDS pathophysiology. Metabolomics offers an avenue to better understand SIDS biology and identifying potential biomarkers.
View Article and Find Full Text PDFInterference fit of cementless tibial implants and the initial mechanical environment: A micro-CT and DVC study.
J Orthop Res
February 2025
Medical Device Research Institute, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia.
During cementless total knee arthroplasty (TKA), an overlap between the resected tibia and the implant's geometry, termed interference fit, is introduced to facilitate primary stability and direct bone-implant contact. However, little is known about the actual interference achieved and the resulting mechanical response in the surrounding cancellous bone. The aim of this study was (1) to experimentally quantify the actual interference achieved for a commercially available cementless tibial implant and (2) to assess its effect on the post-impaction cancellous bone strain.
View Article and Find Full Text PDFIntegrated multimodal cell atlas of Alzheimer's disease.
Nat Neurosci
December 2024
Allen Institute for Brain Science, Seattle, WA, USA.
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized by stereotyped accumulation of proteinopathies, the affected cellular populations remain understudied. Here we use multiomics, spatial genomics and reference atlases from the BRAIN Initiative to study middle temporal gyrus cell types in 84 donors with varying AD pathologies.
View Article and Find Full Text PDFThe appearance of misfolded and aggregated proteins is a pathological hallmark of numerous neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Sleep disruption is proposed to contribute to these pathological processes and is a common early feature among neurodegenerative disorders. Synucleinopathies are a subclass of neurodegenerative conditions defined by the presence of α-synuclein aggregates, which may not only enhance cell death, but also contribute to disease progression by seeding the formation of additional aggregates in neighboring cells.
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