Objectives: To recommend how the description of clinically detectable treatment effects might be improved for antidementia drug trials.
Method: Consensus conference, with review of available evidence.
Results: We suggest widespread, systematic, qualitative studies, based on prospective observations such as the clinicians' narrative descriptions of patient's changes used in the Clinician's Interview-Based Impressions of Change (CIBIC-Plus), plus caregiver input. The identification of patient and caregiver expectations, and an understanding of how these expectations are met, are proposed as priorities for future study.
Conclusion: Better descriptions of treatment effects can enhance our understanding of both clinical meaningfulness and cholinergic function in the brain.
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