Proper oxygenation is critical to prevent hypoxia and myocardial ischemia in animals during pharmacological sedation. The authors compared the efficacy of two oxygen delivery masks during sedation and spinal anesthesia for knee surgery in sheep.
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http://dx.doi.org/10.1038/5000200 | DOI Listing |
J Biosci Bioeng
January 2025
Department of Biology, College of Science, Shantou University, Shantou 515063, Guangdong, China; Guangdong Provincial Key Laboratory of Marine Biotechnology, Institute of Marine Sciences, Shantou University, Shantou 515063, China; Shantou Key Laboratory of Marine Microbial Resources and Interactions with Environment, Shantou University, Shantou 515063, China. Electronic address:
Oxidative stress, caused by excessive production of reactive oxygen species (ROS), plays a crucial role in the occurrence and development of various diseases. Monascin can scavenge ROS and alleviate oxidative stress but with a low fermentation rate and bioavailability. Here, we optimized the fermentation process to increase the production of monascin (508.
View Article and Find Full Text PDFJ Control Release
January 2025
College of pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China. Electronic address:
The process of regenerating bone injuries in diabetic presents significant challenges because lysine oxidase (LOX), a key catalytic enzyme for collagen cross-linking, is inhibited in hyperglycemia. The supplementation of LOX is constrained by inadequate sources and diminished enzymatic activity, necessitating the development of effective alternatives for enhancing bone regeneration in diabetes. Herein, we reported a lysyl oxidase nanozyme (LON), derived from the catalytic domain of LOX.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Department of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, PR China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan 646000, PR China. Electronic address:
As one of the most commonly used chemotherapeutic agents in clinical practice, cisplatin is unable to selectively accumulate in tumor tissue due to its lack of targeting ability, leading to increased systemic toxicities. Additionally, the effectiveness of monotherapy is greatly limited. Therefore, the development of new cisplatin-based drug delivery systems is essential to improve the effectiveness of tumor treatment.
View Article and Find Full Text PDFFree Radic Biol Med
January 2025
University of Colorado, Anschutz Medical Campus School of Medicine| Translational research laboratory of Red Blood Cell Diseases and Hypoxia related illnesses| Cardiovascular Pulmonary Research (CVP) group, Pediatrics. Electronic address:
Lung tissue from human patients and murine models of sickle cell disease pulmonary hypertension (SCD-PH) show perivascular regions with excessive iron accumulation. The iron accumulation arises from chronic hemolysis and extravasation of hemoglobin (Hb) into the lung adventitial spaces, where it is linked to nitric oxide depletion, oxidative stress, inflammation, and tissue hypoxia, which collectively drive SCD-PH. Here, we tested the hypothesis that intrapulmonary delivery of hemopexin (Hpx) to the deep lung is effective at scavenging heme-iron and attenuating the progression of SCD-PH.
View Article and Find Full Text PDFWater Res
January 2025
NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Shandong, Jinan 250012, China; Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, Jinan 250021, China; Key Laboratory of Chemical Biology (Ministry of Education), Shandong University, Shandong, Jinan 250012, China; Shandong Engineering Research Center for Transdermal Drug Delivery Systems, Shandong, Jinan 250098, China. Electronic address:
Water quality monitoring is one of the critical aspects of industrial wastewater treatment, which is important for checking the treatment effect, optimizing the treatment technology and ensuring that the water quality meets the standard. Chemical oxygen demand (COD) is a key indicator for monitoring water quality, which reflects the degree of organic matter pollution in water bodies. However, the current methods for determining COD values have drawbacks such as slow speed and complicated operation, which hardly meet the demand of online monitoring.
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