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Effects of nicotine and cotinine on bovine theca interna and granulosa cells. | LitMetric
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Effects of nicotine and cotinine on bovine theca interna and granulosa cells.

Sara R Sanders S Peder Cuneo Adele M Turzillo

Reprod Toxicol

Department of Physiology, University of Arizona, PO Box 245051, 85724-4347, Tucson, AZ, USA

Published: April 2003

The purpose of this study was to determine if nicotine or cotinine inhibits steroidogenesis in the ovarian follicle. Theca interna and granulosa cells were isolated from bovine follicles, cultured with nicotine or cotinine for 24h, and culture media were assayed for androstenedione or estradiol. Treatment of theca interna with 6, 60, and 600 micro M nicotine decreased (P

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http://dx.doi.org/10.1016/s0890-6238(02)00049-7DOI Listing

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