The absolute configuration of (+)-2,7(14),10-bisabolatrien-1-ol-4-one, a peculiar sesquiterpenol in the Japanese cedar, Cryptomeria japonica, was determined as (1S,6R)-2,7(14),10-bisabolatrien-1-ol-4-one by comparing the specific rotation values of cryptomeriones respectively converted from (+)-2,7(14),10-bisabolatrien-1-ol-4-one and synthesized from (R)-(-)-carvone.
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http://dx.doi.org/10.1271/bbb.66.1997 | DOI Listing |
RSC Adv
January 2025
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University Alexandria 21521 Egypt
A microwave-assisted method was utilized to synthesize novel pyranoquinolone derivatives as dual acting topoisomerase II/DNA gyrase inhibitors with apoptosis induction ability for halting lung cancer and staphylococcal infection. Herein, the designed rationale was directed toward mimicking the structural features of both topoisomerase II and DNA gyrase inhibitors as well as endowing them with apoptosis induction potential. The absolute configuration of the series was assigned using X-ray diffraction analysis.
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January 2025
Key Laboratory of Functional Molecules Analysis and Biotransformation of Universities in Yunnan Province, Yunnan Characteristic Plant Extraction Laboratory, School of Chemical Science and Technology, School of Medicine, Yunnan University Kunming Yunnan 650500 PR China
The natural products of 2,5-diketopiperazines have attracted considerable attention due to their potent pharmacological activities. Guided by genome mining techniques, five albonoursin analogues, designated as albocandins A-E (1-5), were isolated from sp. YINM00030, an actinomycete sourced from the rhizosphere soil of medicinal plants.
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January 2025
Lanzhou University, School of Pharmacy, 199 West Donggang Road, 730000, Lanzhou, CHINA.
A new oleanane-type triterpenoid, 3β-acetyl-15α-hydroxy-oleanane-13β,28-olide (1), and a new clerodane furanoditerpenoid, cnidophyllin A (2), together with eleven known compounds (3-13) were isolated and identified from the 95% EtOH extract of the leaves and twigs of Croton cnidophyllus. Except for compounds 3 and 7, all other compounds were isolated for the first time from C. cnidophyllus.
View Article and Find Full Text PDFPhytochemistry
January 2025
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi 830011, Xinjiang, China; University of Chinese Academy of Sciences, Beijing 100039, China; College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China. Electronic address:
Twelve flavonoid glycosides including five undescribed ones, lepisativutimines Q-U, were isolated and identified from Lepidium sativum seeds. Acid hydrolysis followed by acetic derivatization and GC analysis were conducted to determine the absolute configurations for sugars. Lepisativutimine U and beitingxinhuangtong A were uncommon kaempferol 8-S-glycosides, and complete NMR data of beitingxinhuangtong A were provided for the first time.
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January 2025
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education+Traditional Chinese medicine (TCM) biological genetics (Heilongjiang province double first-class construction interdiscipline), Heilongjiang University of Chinese Medicine, Harbin 150040, China. Electronic address:
Nine previously undescribed chromones, named sadivamones O-W (1-9), and five known analogues (10-14), were isolated from the roots of Saposhnikovia divaricata (Turcz.) Schischk. The detailed structural analysis of each compound was finalized by a variety of methods including NMR (1D and 2D), mass spectrometry (HR-ESI-MS) spectroscopic data, and sugar hydrolysis.
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