In the last years the research on the etiopathogenesis of the inflammatory bowel disease (IBD) is focused around immunological aspects. Many authors consider that the intestinal inflammation is due to an inappropriate immunological response to normally present antigens in the gut. Two aspects must to be considered between IBD: Crohn's disease and ulcerative colitis. IBD's diagnosis is based on the symptomatology, (cramps, liquid feces with mucus and blood, anorexia and weight loss), hemato-clinical tests (ESR, PCR, blood platelet, mucoprotein, sideremia) and radiological tests (tenuis Rx, abdominal echography, fibro endoscophy and scintigraphy). Principal aim of the therapy is the clinical remission. Following the remission starts a maintenance protocol. Parenteral nutrition is used in paediatric and adolescent age. Diets have been used to provide a convenient nutritious contribution with growth improvement and partial remission of activity index of the disease. Pharmacology therapy represents a valid instrument to obtain the remission. Colectomy is performed on unsuccessful medical therapy. Early studies on IBD's pathogenesis bring to the use of biological therapies that show beneficial effects on the disease.
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Ital J Pediatr
January 2025
Department of Pediatrics, IRCCS Policlinico San Matteo Foundation, Viale Golgi 19, Pavia, 27100, Italy.
Background: Chronic Nonbacterial Osteomyelitis (CNO) is a rare auto-inflammatory disease that mainly affects children, and manifests with single or multiple painful bone lesions. Due to the lack of specific laboratory markers, CNO diagnosis is a matter of exclusion from different conditions, first and foremost bacterial osteomyelitis and malignancies. Whole Body Magnetic Resonance (WBMR) and bone biopsy are the gold standard for the diagnosis.
View Article and Find Full Text PDFSci Rep
January 2025
School of Health Preservation and Rehabilitation, Chengdu University of TCM, Shierqiao Road, Chengdu, 610075, Sichuan, People's Republic of China.
Despite the established link between chronic high salt diet (HSD) and an increase in gut inflammation, the effect of HSD on the integrity of the intestinal barrier remains understudied. The present study aims to investigate the impact of HSD on the intestinal barrier in rats, encompassing its mechanical, mucous, and immune components. Expression levels of intestinal tight junction proteins and mucin-2 (MUC2) in SD rats were analyzed using immunofluorescence.
View Article and Find Full Text PDFActa Biomater
January 2025
School of Life Sciences, Chongqing University, Chongqing, 400044, China.. Electronic address:
Ulcerative colitis (UC) is a prevalent gastrointestinal disease characterized by the chronical and refractory inflammation of colorectal mucosa and walls, which severely impairs overall well-being of individuals. Probiotics has shown tremendous promise for UC therapy due to its multifaceted mucosal barrier restoration and immunomodulation capabilities. Nevertheless, the successful administration of probiotics remains a clinical obstacle.
View Article and Find Full Text PDFJ Trace Elem Med Biol
January 2025
Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address:
Magnesium (Mg) is essential for life, and low levels impair immune function, promote chronic inflammation, and influence the intestinal microbiome, with the peritoneal cavity serving as a site for direct interaction between the cavity and intestinal contents, including the microbiota. This study investigates the effects of a Mg-restricted diet on peritoneal immune cells and its interplay with the intestinal microbiome. Male C57BL/6NTaq mice were divided into three groups: control, restricted, and restored.
View Article and Find Full Text PDFEcotoxicol Environ Saf
January 2025
Liaoning Province Key Laboratory for phenomics of Human Ethnic Specificity and Critical Illness, Shenyang Medical College, Shengyang, PR China. Electronic address:
Aim: Long-term exposure to excess sodium fluoride (NaF) can cause chronic fluorosis. Liver, the most important detoxification organ, is the most vulnerable to the effects of fluoride. Sodium butyrate (NaB), a short-chain fatty acid produced in the intestinal tract, maintains normal mitochondrial function in vivo and reduces liver inflammation and oxidative stress.
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