An anhydrophytosphingosine named pachastrissamine (3) has been isolated as a cytotoxic principle of a sponge, Pachastrissa sp., and the structure including the absolute configuration determined by spectroscopic and chemical analysis.
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Kabiramide L, a new antiplasmodial trisoxazole macrolide from the sponge Pachastrissa nux.
Nat Prod Res
January 2014
Marine Natural Products Research Unit, Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
An extensive search for the trisoxazole macrolides in the Thai specimen of the sponge Pachastrissa nux led to the isolation of a new kabiramide derivative, kabiramide L (1) and the previously reported kabiramide I (2). Both macrolides had a moderate antiplasmodial activity against Plasmodium falciparum K1 with IC50s of 2.6 and 4.
View Article and Find Full Text PDFPachastrissamine from Pachastrissa sp. inhibits melanoma cell growth by dual inhibition of Cdk2 and ERK-mediated FOXO3 downregulation.
Phytother Res
December 2012
Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul 137-040, South Korea.
Melanoma cells are relatively resistant to apoptosis compared with other tumor cell types, and thus, chemotherapy, radiotherapy and immunotherapy are not effective in treating melanoma. Pachastrissamine (PA) exhibits cytotoxic activity and promotes apoptosis in several cancer cells. However, its specific molecular mechanisms have not been characterized fully.
View Article and Find Full Text PDFIntracolonial allocation of trisoxazole macrolides in the sponge Pachastrissa nux.
Chem Biodivers
December 2011
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, Thailand.
Pachastrissa nux has two distinctive growth forms in one colony, i.e., the protruding gorgonian-shaped capitum and the substratum-attached irregular-shaped base.
View Article and Find Full Text PDFKabiramides J and K, trisoxazole macrolides from the sponge Pachastrissa nux.
J Nat Prod
May 2011
Marine Natural Products Research Unit (MNP), Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
Three trisoxazole macrolides possessing a 30-α,β-enone moiety, including the known kabiramide G (1) and the new kabiramides J (2) and K (3), were isolated from the sponge Pachastrissa nux, along with the previously reported kabiramides B (4), C (5), and D (6). To date, the enone moiety has been found to associate solely with the trisoxazole macrolides from P. nux.
View Article and Find Full Text PDFSkeletons in confusion: a review of astrophorid sponges with (dicho-)calthrops as structural megascleres (Porifera, Demospongiae, Astrophorida).
Zookeys
November 2010
Netherlands Centre for Biodiversity, Zoological Museum of Amsterdam, P.O. Box 94766, 1090 GT Amsterdam, The Netherlands.
We present a review of astrophorid species possessing calthrops megascleres as structural megascleres (including species with dichotriaene modifications, but excluding mesotriaene and trichotriaene bearing species). Radiating oxeas characteristic of most astrophorids are lacking in such sponges, but auxiliary oxeas are apparently present in some species. These sponges are currently assigned to two families, Pachastrellidae with four nominal genera Dercitus, Stoeba, Dercitancorina, Halinastra (the latter two generally considered junior synonyms of Stoeba), and Calthropellidae with nominal genera Calthropella, Corticellopsis (usually considered a junior synonym), Pachataxa and Pachastrissa.
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